Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.61 |
| ▸ | RET | P07949 | 1/20 | 0.61 |
| ▸ | KIF5B | P33176 | 1/20 | 0.61 |
| ▸ | EGFR | P00533 | 12/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.59 |
| ▸ | EPHB4 | P54760 | 5/20 | 0.59 |
| ▸ | CLK1 | P49759 | 2/20 | 0.59 |
| ▸ | FBP1 | P09467 | 2/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | INSR | P06213 | 1/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.59 |
| ▸ | FLT4 | P35916 | 1/20 | 0.59 |
| ▸ | TEK | Q02763 | 1/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.59 |
| ▸ | FLT1 | P17948 | 1/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.57 |
| ▸ | SRC | P12931 | 2/20 | 0.57 |
| ▸ | EPHA2 | P29317 | 6/20 | 0.56 |
| ▸ | LCK | P06239 | 3/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5650446 | 0.94 | KDR (0.65) | KDRRETKIF5BEGFRERBB2 | |
| SCHEMBL5647432 | 0.89 | KDR (0.61) | KDRRETKIF5BEGFRERBB2 | |
| SCHEMBL5652556 | 0.87 | EGFR (0.69) | KDREGFRERBB2EPHB4SRC | |
| SCHEMBL5651856 | 0.86 | KDR (0.59) | KDRRETKIF5BEGFRERBB2 | |
| SCHEMBL5650271 | 0.86 | EPHA2 (0.71) | KDREGFRERBB2EPHB4EPHA2 | |
| SCHEMBL5652242 | 0.86 | KDR (0.69) | KDREGFRCLK1FBP1FLT1 | |
| SCHEMBL5647981 | 0.85 | EGFR (0.62) | KDRRETEGFRCLK1AURKA | |
| SCHEMBL5652007 | 0.85 | KDR (0.68) | KDREGFRCLK1FBP1FLT1 | |
| SCHEMBL5649679 | 0.83 | KDR (0.53) | KDRRETKIF5BEGFRCLK1 | |
| SCHEMBL5647574 | 0.83 | KDR (0.56) | KDREGFRERBB2FBP1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070299092-A1 | Quinone Substituted Quinazoline and Quinoline Kinase Inhibitors | WYETH (US) | 2007-12-27 | — | — | US | claimed |
| WO-2005115145-A2 | QUINONE SUBSTITUTED QUINAZOLINE AND QUINOLINE KINASE INHIBITORS | WYETH (US) | 2005-12-08 | — | — | WO | claimed |
| US-20070299092-A1 | Quinone Substituted Quinazoline and Quinoline Kinase Inhibitors | WYETH (US) | 2007-12-27 | — | — | US | disclosed |
| WO-2005115145-A2 | QUINONE SUBSTITUTED QUINAZOLINE AND QUINOLINE KINASE INHIBITORS | WYETH (US) | 2005-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299092-A1 | Quinone Substituted Quinazoline and Quinoline Kinase Inhibitors | KDR, FLT1, FLT4 | KDR 1/4885RET 81/4885KIF5B 1157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.