Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.59 |
| ▸ | FLT1 | P17948 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 9/20 | 0.55 |
| ▸ | LCK | P06239 | 4/20 | 0.55 |
| ▸ | CLK1 | P49759 | 2/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.53 |
| ▸ | FBP1 | P09467 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | FLT4 | P35916 | 1/20 | 0.52 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.52 |
| ▸ | TEK | Q02763 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5651546 | 0.87 | KDR (0.59) | KDRFLT1EGFRLCKFBP1 | |
| SCHEMBL5654477 | 0.86 | KDR (0.61) | KDRFLT1EGFRLCKCLK1 | |
| SCHEMBL5651894 | 0.86 | KDR (0.59) | KDRFLT1EGFRFBP1HDAC3 | |
| SCHEMBL5649359 | 0.86 | KDR (0.56) | KDRFLT1EGFRLCKFBP1 | |
| SCHEMBL5651948 | 0.86 | KDR (0.56) | KDRFLT1EGFRRIPK2EPHB2 | |
| SCHEMBL5652242 | 0.84 | KDR (0.69) | KDRFLT1EGFRCLK1ABCG2 | |
| SCHEMBL5649902 | 0.84 | KDR (0.55) | KDRFLT1EGFRFBP1HDAC3 | |
| SCHEMBL5652007 | 0.83 | KDR (0.68) | KDRFLT1EGFRCLK1ABCG2 | |
| SCHEMBL5652379 | 0.83 | KDR (0.57) | KDRFLT1EGFRRIPK2EPHB2 | |
| SCHEMBL5646837 | 0.83 | FBP1 (0.57) | KDRFLT1EGFRFBP1EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070299092-A1 | Quinone Substituted Quinazoline and Quinoline Kinase Inhibitors | WYETH (US) | 2007-12-27 | — | — | US | claimed |
| WO-2005115145-A2 | QUINONE SUBSTITUTED QUINAZOLINE AND QUINOLINE KINASE INHIBITORS | WYETH (US) | 2005-12-08 | — | — | WO | claimed |
| US-20070299092-A1 | Quinone Substituted Quinazoline and Quinoline Kinase Inhibitors | WYETH (US) | 2007-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299092-A1 | Quinone Substituted Quinazoline and Quinoline Kinase Inhibitors | KDR, FLT1, FLT4 | KDR 1/4885FLT1 2/4885EGFR 439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.