SCHEMBL5655475

SCHEMBL5655475

O=C(Cl)C(Cl)c1ccc(C(F)(F)F)cc1Cl

nearest known ligand 0.63

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PDE2A O00408 7/20 0.63
CYP1A2 P05177 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
FFAR1 O14842 2/20 0.40
EEF2K O00418 1/20 0.39
CES2 O00748 2/20 0.39
ALDH1A1 P00352 2/20 0.38
MAPT P10636 1/20 0.38
JAK2 O60674 1/20 0.38
JAK1 P23458 1/20 0.38
TYK2 P29597 1/20 0.38
KDM4E B2RXH2 1/20 0.38
MRGPRX4 Q96LA9 1/20 0.37
LMNA P02545 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7823148 0.87 PDE2A (0.63) PDE2ACYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL28308850 0.81 PDE2A (0.44) PDE2ACYP1A2CES2ALDH1A1MAPT
SCHEMBL6644323 0.78 PDE2A (0.65) PDE2ACYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL18075371 0.77 PDE2A (1.00) PDE2ACYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL11321093 0.77 TP53 (0.47) ALDH1A1MAPTKDM4ELMNA
SCHEMBL4633442 0.77 PDE2A (0.63) PDE2ACYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL4633445 0.77 PDE2A (0.63) PDE2ACYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL19914016 0.74 PDE2A (0.59) PDE2ACYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL22279498 0.74 PDE2A (0.59) PDE2AALDH1A1KDM4EMRGPRX4LMNA
SCHEMBL29472442 0.74 PDE2A (0.59) PDE2AALDH1A1KDM4EMRGPRX4LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7183238-B2 [1,2]-oxazine-3,5-diones BAYER CROPSCIENCE AG (DE) 2007-02-27 US disclosed
US-20050070707-A1 microbicides, pesticides and herbicides BAYER CROPSCIENCE AG (DE) 2005-03-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050070707-A1 microbicides, pesticides and herbicides DDT, CX3CR1, MSR1 PDE2A 661/4885CYP1A2 171/4885CYP2D6 121/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.