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SCHEMBL565569

SCHEMBL565569

Cc1cccc(CNCC(C)C(=O)N(Cc2cc(Cl)c3c(c2)OCCCO3)CC(C)C)c1C

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PROKR2 Q8NFJ6 5/20 0.72
▸ MAPK8 P45983 1/20 0.34
▸ KMT2A Q03164 2/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ ACKR3 P25106 1/20 0.32
▸ MTNR1A P48039 1/20 0.32
▸ MAP3K7 O43318 1/20 0.31
▸ TAB1 Q15750 1/20 0.31
▸ ALDH1A1 P00352 3/20 0.31
▸ MAPK1 P28482 1/20 0.30
▸ L3MBTL1 Q9Y468 1/20 0.30
▸ NPC1 O15118 2/20 0.30
▸ RAB9A P51151 2/20 0.30
▸ SMN1; SMN2 Q16637 1/20 0.30
▸ USP2 O75604 1/20 0.30
▸ TSHR P16473 1/20 0.30
▸ KDM4E B2RXH2 1/20 0.30
▸ HDAC3 O15379 1/20 0.30
▸ HDAC4 P56524 1/20 0.30
▸ HDAC1 Q13547 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL565287 0.94 PROKR2 (0.72) PROKR2MAPK8KMT2AMEN1ALDH1A1
SCHEMBL13284393 0.92 PROKR2 (0.62) PROKR2KMT2AMEN1MTNR1AMAP3K7
SCHEMBL564958 0.91 PROKR2 (0.70) PROKR2MAPK8KMT2AMEN1MTNR1A
SCHEMBL564396 0.91 PROKR2 (0.68) PROKR2MAPK8ALDH1A1NPC1RAB9A
SCHEMBL564206 0.91 PROKR2 (0.75) PROKR2MAPK8MTNR1AMAP3K7TAB1
SCHEMBL565413 0.91 PROKR2 (0.69) PROKR2MAPK8KMT2AMEN1MTNR1A
SCHEMBL565414 0.90 PROKR2 (0.74) PROKR2MAPK8KMT2AACKR3ALDH1A1
SCHEMBL565130 0.89 PROKR2 (0.73) PROKR2MAPK8KMT2AMEN1ACKR3
SCHEMBL10107480 0.89 PROKR2 (0.58) PROKR2KMT2AMEN1ACKR3
SCHEMBL565621 0.89 PROKR2 (0.72) PROKR2MAPK8MTNR1AMAP3K7TAB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8722896-B2 Prokineticin receptor antagonists and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-05-13 — — US disclosed
US-8722896-B2 Prokineticin receptor antagonists and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-05-13 — — US disclosed
US-8722896-B2 Prokineticin receptor antagonists and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-05-13 — — US disclosed
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-09 — — US disclosed
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-09 — — US disclosed
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof PROKR2, PROKR1, GIPR PROKR2 1/4885MAPK8 1270/4885KMT2A 4644/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.