Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | HASPIN | Q8TF76 | 4/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29986726 | 0.79 | IMPDH2 (0.46) | IMPDH2MAPTLMNACYP1A2CYP3A4 | |
| SCHEMBL31552249 | 0.76 | IMPDH2 (0.61) | IMPDH2MAPTLMNACYP1A2CYP3A4 | |
| SCHEMBL1705034 | 0.76 | IMPDH2 (0.61) | IMPDH2MAPTLMNACYP1A2CYP3A4 | |
| SCHEMBL3716490 | 0.76 | IMPDH2 (0.61) | IMPDH2MAPTLMNACYP1A2CYP3A4 | |
| SCHEMBL30481278 | 0.76 | IMPDH2 (0.61) | IMPDH2LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7842033 | 0.76 | ERN1 (0.56) | IMPDH2LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6832863 | 0.76 | IMPDH2 (0.61) | IMPDH2LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4829442 | 0.76 | IMPDH2 (0.52) | IMPDH2MAPTLMNACYP1A2CYP3A4 | |
| SCHEMBL5658470 | 0.76 | IMPDH2 (0.47) | IMPDH2MAPTLMNACYP1A2CYP3A4 | |
| SCHEMBL6622525 | 0.76 | IMPDH2 (0.47) | IMPDH2LMNACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115055128-A | Preparation method of cyclopropyl-substituted nitrogen-containing six-membered heterocyclic compound | 北京六合宁远医药科技股份有限公司 | 2022-09-16 | — | — | CN | claimed |
| CN-115055128-A | Preparation method of cyclopropyl-substituted nitrogen-containing six-membered heterocyclic compound | 北京六合宁远医药科技股份有限公司 | 2022-09-16 | — | — | CN | disclosed |
| US-7285563-B2 | Heteroaromatic urea derivatives as VR-1 receptor modulators for treating pain | MERCK SHARP & DOHME LTD. (GB) | 2007-10-23 | — | — | US | disclosed |
| US-20050107388-A1 | Heteroaromatic urea derivatives as vr-1receptor modulators for treating pain | MERCK SHARP & DOHME LTD. (GB) | 2005-05-19 | — | — | US | disclosed |
| EP-1490340-A1 | HETEROAROMATIC UREA DERIVATIVES AS VR-1 RECEPTOR MODULATORS FOR TREATING PAIN | MERCK SHARP & DOHME LTD. (GB) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003080578-A1 | HETEROAROMATIC UREA DERIVATIVES AS VR-1 RECEPTOR MODULATORS FOR TREATING PAIN | MERCK SHARP & DOHME LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107388-A1 | Heteroaromatic urea derivatives as vr-1receptor modulators for treating pain | ARRB1, OPRL1, CNR1 | IMPDH2 3396/4885MAPT 4195/4885LMNA 2921/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.