Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.38 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 3/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5654405 | 0.85 | MKNK1 (0.56) | CNR1ERN1MKNK1MKNK2CYP2A6 | |
| SCHEMBL8348566 | 0.79 | ERN1 (0.50) | CNR1CNR2ATMERN1CYP2A6 | |
| SCHEMBL3661330 | 0.76 | CCNT1 (0.52) | ERN1MKNK1MKNK2KAT6AKMO | |
| SCHEMBL17127157 | 0.75 | ATM (0.48) | CNR1CNR2ATMERN1MKNK1 | |
| SCHEMBL5458318 | 0.75 | ATM (0.48) | CNR1CNR2ATMERN1MKNK1 | |
| SCHEMBL5654037 | 0.75 | PIM2 (0.67) | KMOABL1PIM2 | |
| SCHEMBL5675922 | 0.75 | MAP4K4 (0.44) | MKNK1MKNK2CYP2A6TRIM24TRIM33 | |
| SCHEMBL5849078 | 0.75 | CYP2A6 (0.45) | ERN1MKNK1MKNK2CYP2A6TRIM24 | |
| SCHEMBL4313820 | 0.73 | HCAR2 (0.42) | IKBKBCHUKPKN1PKN2 | |
| SCHEMBL22089054 | 0.73 | ATM (0.67) | CNR1CNR2ATMERN1MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091202-B2 | 4-arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ potassium channel modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-08-15 | — | — | US | disclosed |
| US-20060063790-A1 | 4-Arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ potassium channel modulators | BRISTOL-MYERS SQUIBB COMPANY | 2006-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063790-A1 | 4-Arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ potassium channel modulators | KCNQ2, KCNQ1, KCNQ4 | CNR1 166/4885CNR2 170/4885ATM 4559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.