SCHEMBL565612

SCHEMBL565612

Cc1cc(O[Si](C)(C)C(C)(C)C)cc(F)c1Br

nearest known ligand 0.36

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CA12 O43570 4/20 0.36
CA1 P00915 4/20 0.36
CA9 Q16790 4/20 0.36
PREP P48147 2/20 0.34
APLNR P35414 2/20 0.32
ALOX5AP P20292 1/20 0.31
FEN1 P39748 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28697821 0.89 CA12 (0.39) CA12CA1CA9PREPAPLNR
SCHEMBL1250704 0.87 CA12 (0.40) CA12CA1CA9PREP
SCHEMBL23190370 0.80 CA12 (0.40) CA12CA1CA9PREPAPLNR
SCHEMBL26963167 0.79 CA12 (0.36) CA12CA1CA9PREPAPLNR
SCHEMBL29860065 0.79 CA12 (0.36) CA12CA1CA9PREPAPLNR
SCHEMBL4977539 0.77 CA12 (0.46) CA12CA1CA9PREPAPLNR
SCHEMBL17318153 0.74 CA12 (0.47) CA12CA1CA9PREPALOX5AP
SCHEMBL5993610 0.74 CA12 (0.39) CA12CA1CA9PREP
SCHEMBL10013790 0.74 CA12 (0.39) CA12CA1CA9PREP
SCHEMBL2059379 0.74 CA1 (0.39) CA12CA1CA9PREP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12479844-B2 Ion channel modulators PRAXIS PRECISION MEDICINES, INC. (US) 2025-11-25 US disclosed
US-20210403476-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. 2021-12-30 US disclosed
CN-113573713-A Ion channel modulators 普拉克西斯精密药物股份有限公司 2021-10-29 CN disclosed
EP-3856193-A1 ION CHANNEL MODULATORS Praxis Precision Medicines, Inc. (US) 2021-08-04 EP disclosed
WO-2020069322-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. (US) 2020-04-02 WO disclosed
US-9499570-B2 Boron containing small molecules ANACOR PHARMACEUTICALS, INC. (US) 2016-11-22 US disclosed
US-20150376210-A1 BORON-CONTAINING SMALL MOLECULES ANACOR PHARMACEUTICALS, LLC 2015-12-31 US disclosed
US-9145429-B2 Boron-containing small molecules ANACOR PHARMACEUTICALS, INC. (US) 2015-09-29 US disclosed
US-20140200198-A1 BORON-CONTAINING SMALL MOLECULES ANACOR PHARMACEUTICALS, INC. (US) 2014-07-17 US disclosed
US-8716478-B2 Boron-containing small molecules ANACOR PHARMACEUTICALS, INC. (US) 2014-05-06 US disclosed
US-20120035132-A1 BORON-CONTAINING SMALL MOLECULES ANACOR PHARMACEUTICALS, INC. (US) 2012-02-09 US disclosed
WO-2011094450-A1 BORON-CONTAINING SMALL MOLECULES ANACOR PHARMACEUTICALS, INC (US) 2011-08-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210403476-A1 ION CHANNEL MODULATORS SCN1A, SCN3A, SCN2A CA12 4024/4885CA1 1172/4885CA9 3810/4885
US-20140200198-A1 BORON-CONTAINING SMALL MOLECULES BTD, BCL6B, BBOX1 CA12 347/4885CA1 1315/4885CA9 339/4885
US-12479844-B2 Ion channel modulators SCN1A, SCN3A, SCN2A CA12 4024/4885CA1 1172/4885CA9 3810/4885
US-20120035132-A1 BORON-CONTAINING SMALL MOLECULES BTD, BCL6B, BBOX1 CA12 347/4885CA1 1315/4885CA9 339/4885
US-20150376210-A1 BORON-CONTAINING SMALL MOLECULES BTD, BCL6B, BBOX1 CA12 347/4885CA1 1315/4885CA9 339/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.