Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 14/20 | 0.50 |
| ▸ | IDH1 | O75874 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | NOS2 | P35228 | 2/20 | 0.49 |
| ▸ | PGR | P06401 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ESRRA | P11474 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2379685 | 0.89 | ALDH1A1 (0.56) | ARIDH1PGRKDM4EUSP2 | |
| SCHEMBL9951140 | 0.87 | AR (0.56) | ARIDH1PGRKDM4EUSP2 | |
| SCHEMBL5367048 | 0.86 | AR (0.46) | ARIDH1PGRKDM4EUSP2 | |
| SCHEMBL4623317 | 0.84 | AR (0.50) | ARIDH1PGRKDM4EUSP2 | |
| SCHEMBL2090152 | 0.82 | CYP2C19 (0.41) | ARIDH1KDM4EUSP2ALDH1A1 | |
| SCHEMBL3578065 | 0.81 | AR (0.52) | ARIDH1CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL2553151 | 0.81 | CYP2D6 (0.55) | ARIDH1CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL2526268 | 0.79 | AR (0.53) | ARPGRESRRA | |
| SCHEMBL5338649 | 0.79 | ESRRA (0.59) | ARALDH1A1ESRRA | |
| SCHEMBL299402 | 0.78 | AR (0.45) | ARIDH1PGRKDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7285563-B2 | Heteroaromatic urea derivatives as VR-1 receptor modulators for treating pain | MERCK SHARP & DOHME LTD. (GB) | 2007-10-23 | — | — | US | disclosed |
| US-20050107388-A1 | Heteroaromatic urea derivatives as vr-1receptor modulators for treating pain | MERCK SHARP & DOHME LTD. (GB) | 2005-05-19 | — | — | US | disclosed |
| EP-1490340-A1 | HETEROAROMATIC UREA DERIVATIVES AS VR-1 RECEPTOR MODULATORS FOR TREATING PAIN | MERCK SHARP & DOHME LTD. (GB) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003080578-A1 | HETEROAROMATIC UREA DERIVATIVES AS VR-1 RECEPTOR MODULATORS FOR TREATING PAIN | MERCK SHARP & DOHME LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |
| US-5474998-A | Pesticides | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1995-12-12 | — | — | US | disclosed |
| EP-0543930-A1 | ARTHROPODICIDAL PYRAZOLINES, PYRAZOLIDINES AND HYDRAZINES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |
| WO-1992003421-A2 | ARTHROPODICIDAL PYRAZOLINES, PYRAZOLIDINES AND HYDRAZINES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-03-05 | — | — | WO | disclosed |
| EP-0463090-A1 | ARTHROPODICIDAL TETRAHYDROBENZOPYRANOPYRAZOLES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-01-02 | — | — | EP | disclosed |
| WO-1990010623-A2 | ARTHROPODICIDAL TETRAHYDROBENZOPYRANOPYRAZOLES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-09-20 | — | — | WO | disclosed |
| EP-0386892-A2 | Arthropodicidal tetrahydrobenzopyranopyrazoles | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-09-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107388-A1 | Heteroaromatic urea derivatives as vr-1receptor modulators for treating pain | ARRB1, OPRL1, CNR1 | AR 225/4885IDH1 4380/4885CYP2D6 550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.