Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.85 |
| ▸ | MERTK | Q12866 | 4/20 | 0.53 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.53 |
| ▸ | GAS6 | Q14393 | 3/20 | 0.53 |
| ▸ | FLT3 | P36888 | 2/20 | 0.53 |
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.44 |
| ▸ | CLK1 | P49759 | 3/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | CLK3 | P49761 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13987027 | 0.92 | GSK3B (1.00) | GSK3BMERTKTYRO3GAS6FLT3 | |
| SCHEMBL4856852 | 0.86 | GSK3B (0.66) | GSK3BMERTKTYRO3GAS6FLT3 | |
| SCHEMBL5235357 | 0.86 | GSK3B (0.66) | GSK3BMERTKTYRO3GAS6FLT3 | |
| SCHEMBL4857179 | 0.81 | GSK3B (0.65) | GSK3BMERTKEIF2AK2 | |
| SCHEMBL5230846 | 0.80 | GSK3B (0.76) | GSK3BMERTKTYRO3GAS6FLT3 | |
| SCHEMBL13987017 | 0.78 | GSK3B (0.67) | GSK3BMERTKTYRO3GAS6FLT3 | |
| SCHEMBL4853882 | 0.77 | GSK3B (0.55) | GSK3BCDK2CLK1DYRK1ACLK4 | |
| SCHEMBL5658993 | 0.76 | GSK3B (0.73) | GSK3B | |
| SCHEMBL4854591 | 0.76 | GSK3B (0.61) | GSK3BRECQLALDH1A1HPGDKDM4E | |
| SCHEMBL5233303 | 0.74 | GSK3B (0.62) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |