Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.76 |
| ▸ | MERTK | Q12866 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | CLK1 | P49759 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 4/20 | 0.38 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | PTAFR | P25105 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5235357 | 0.92 | GSK3B (0.66) | GSK3BMERTKFLT3TYRO3GAS6 | |
| SCHEMBL5244050 | 0.90 | GSK3B (0.61) | GSK3BCDK2CLK1DYRK1ACLK4 | |
| SCHEMBL13987027 | 0.86 | GSK3B (1.00) | GSK3BMERTKFLT3TYRO3GAS6 | |
| SCHEMBL5243802 | 0.85 | GSK3B (0.55) | GSK3BPTAFRNAMPT | |
| SCHEMBL5656460 | 0.80 | GSK3B (0.85) | GSK3BMERTKFLT3TYRO3GAS6 | |
| SCHEMBL5231224 | 0.78 | GSK3B (0.46) | GSK3BPTAFRNAMPTHDAC3HDAC1 | |
| SCHEMBL5231115 | 0.78 | GSK3B (0.46) | GSK3BGSK3APTAFRNAMPTHDAC3 | |
| SCHEMBL5242783 | 0.76 | PTAFR (0.49) | GSK3BPTAFRHDAC3HDAC1HDAC2 | |
| SCHEMBL4857179 | 0.72 | GSK3B (0.65) | GSK3BMERTKEIF2AK2 | |
| SCHEMBL5234145 | 0.72 | DYRK1A (0.44) | GSK3BCDK2CLK1DYRK1ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611121-B1 | PYRIDAZINONE DERIVATIVES AS CDK2-INHIBITORS | AVENTIS PHARMA SA (FR) | 2007-08-08 | — | — | EP | claimed |
| EP-1581505-B1 | PYRIDAZINONE DERIVATIVES AS GSK-3BETA INHIBITORS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-08-01 | — | — | EP | claimed |