Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 7/20 | 0.48 |
| ▸ | CCR3 | P51677 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 2/20 | 0.43 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5369447 | 0.88 | HRH1 (0.56) | HRH1CCR3KDM4EFPR2PROKR1 | |
| SCHEMBL5194926 | 0.81 | HRH1 (0.62) | HRH1CCR3KCNH2 | |
| SCHEMBL5102799 | 0.80 | HRH1 (0.59) | HRH1CCR3KDM4EFPR2PROKR1 | |
| SCHEMBL16483447 | 0.80 | SLC6A2 (0.49) | NPC1HRH1CCR3KDM4EHRH3 | |
| SCHEMBL5345951 | 0.79 | SMN1; SMN2 (0.43) | NPC1HRH1CCR3KDM4EHTR1A | |
| SCHEMBL13176831 | 0.78 | HRH1 (0.49) | HRH1CCR3HTR1AHTR7FPR2 | |
| SCHEMBL5099023 | 0.78 | HRH3 (0.44) | HRH1CCR3HRH3DRD2HTR2A | |
| SCHEMBL4966059 | 0.78 | HRH1 (0.56) | HRH1CCR3KCNH2 | |
| Trifluoroacetic Acid SCHEMBL6396297 | 0.77 | CCR3 (0.53) | HRH1CCR3KCNH2 | |
| SCHEMBL16483395 | 0.77 | NPC1 (0.47) | NPC1HRH1CCR3KDM4EHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7304077-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2007-12-04 | — | — | US | disclosed |
| US-20040102432-A1 | Chemical compounds | ASTRAZENECA AB (SE) | 2004-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102432-A1 | Chemical compounds | CCL11, HRH1, HRH4 | NPC1 842/4885HRH1 2/4885CCR3 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.