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SCHEMBL565706

SCHEMBL565706

Cc1ccccc1CN1CCOC(C(=O)N(Cc2cc(Cl)c3c(c2)OCCCO3)CC(C)C)C1

nearest known ligand 0.75

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ PROKR2 Q8NFJ6 5/20 0.75
▸ DRD4 P21917 1/20 0.39
▸ ALDH1A1 P00352 2/20 0.37
▸ SMN1; SMN2 Q16637 2/20 0.37
▸ KDM4E B2RXH2 1/20 0.37
▸ HPGD P15428 1/20 0.37
▸ HSD17B10 Q99714 1/20 0.37
▸ GRN P28799 1/20 0.35
▸ SORT1 Q99523 1/20 0.35
▸ RECQL P46063 1/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ MEN1 O00255 1/20 0.35
▸ GRIN2B Q13224 1/20 0.34
▸ ACKR3 P25106 1/20 0.34
▸ CYP2A13 Q16696 1/20 0.33
▸ CYP3A4 P08684 1/20 0.33
▸ CYP2D6 P10635 1/20 0.33
▸ CYP2C19 P33261 1/20 0.33
▸ RXRB P28702 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL564199 0.95 PROKR2 (0.74) PROKR2DRD4ALDH1A1SMN1; SMN2KDM4E
SCHEMBL565016 0.92 PROKR2 (0.69) PROKR2DRD4ALDH1A1SMN1; SMN2KDM4E
SCHEMBL565513 0.92 PROKR2 (0.76) PROKR2DRD4ALDH1A1SMN1; SMN2KDM4E
SCHEMBL20936053 0.91 PROKR2 (0.77) PROKR2DRD4ALDH1A1KDM4EGRIN2B
SCHEMBL565611 0.90 PROKR2 (0.73) PROKR2ALDH1A1SMN1; SMN2KDM4EHPGD
SCHEMBL565344 0.89 PROKR2 (0.75) PROKR2ALDH1A1SMN1; SMN2KDM4EKMT2A
SCHEMBL10107537 0.89 PROKR2 (0.73) PROKR2ALDH1A1SMN1; SMN2KDM4EHPGD
SCHEMBL565844 0.89 PROKR2 (0.75) PROKR2ALDH1A1SMN1; SMN2KDM4EKMT2A
SCHEMBL10106731 0.89 PROKR2 (0.75) PROKR2ALDH1A1SMN1; SMN2KDM4EKMT2A
SCHEMBL565456 0.87 PROKR2 (0.70) PROKR2ALDH1A1SMN1; SMN2KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8722896-B2 Prokineticin receptor antagonists and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-05-13 — — US disclosed
US-8722896-B2 Prokineticin receptor antagonists and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-05-13 — — US disclosed
US-8722896-B2 Prokineticin receptor antagonists and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-05-13 — — US disclosed
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-09 — — US disclosed
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-09 — — US disclosed
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof PROKR2, PROKR1, GIPR PROKR2 1/4885DRD4 2872/4885ALDH1A1 4725/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.