Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCB | P05771 | 14/20 | 0.57 |
| ▸ | PRKCA | P17252 | 14/20 | 0.57 |
| ▸ | GSK3B | P49841 | 13/20 | 0.57 |
| ▸ | PRKCG | P05129 | 12/20 | 0.57 |
| ▸ | PRKCD | Q05655 | 8/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.47 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.47 |
| ▸ | MYLK | Q15746 | 2/20 | 0.37 |
| ▸ | PRKCH | P24723 | 2/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.35 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.34 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.33 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3774999 | 0.83 | GSK3B (0.77) | PRKCBPRKCAGSK3BPRKCGPRKCD | |
| SCHEMBL3772597 | 0.80 | PRKCA (0.77) | PRKCBPRKCAGSK3BPRKCGPRKCD | |
| SCHEMBL3774803 | 0.73 | PRKCA (1.00) | PRKCBPRKCAGSK3BPRKCGPRKCD | |
| SCHEMBL3784374 | 0.72 | PRKCA (0.76) | PRKCBPRKCAGSK3BPRKCGPRKCD | |
| SCHEMBL5757963 | 0.70 | PRKCA (0.85) | PRKCBPRKCAGSK3BPRKCGPRKCD | |
| SCHEMBL3779552 | 0.68 | GSK3B (0.78) | PRKCBPRKCAGSK3BPRKCGPRKCD | |
| SCHEMBL1991771 | 0.66 | PRKCA (0.65) | PRKCBPRKCAGSK3BPRKCGPRKCD | |
| SCHEMBL3773391 | 0.66 | PRKCA (0.73) | PRKCBPRKCAGSK3BPRKCGPRKCD | |
| SCHEMBL1993520 | 0.65 | PRKCA (0.64) | PRKCBPRKCAGSK3BPRKCGPRKCD | |
| SCHEMBL3775416 | 0.65 | GSK3B (0.79) | PRKCBPRKCAGSK3BPRKCGPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7304060-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2007-12-04 | — | — | US | disclosed |