Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 9/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.53 |
| ▸ | AURKA | O14965 | 2/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.50 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.50 |
| ▸ | PIM1 | P11309 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 4/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1315419 | 0.87 | SYK (0.55) | SYKMAPK1HTTMAPK8MAPK9 | |
| SCHEMBL15631820 | 0.87 | SYK (0.73) | SYKMAPK1HTTMAPK8EGFR | |
| Fluoride SCHEMBL13518358 | 0.86 | SYK (0.54) | SYKMAPK1HTTMAPK8MAPK9 | |
| SCHEMBL2627255 | 0.84 | SYK (0.53) | SYKMAPK1HTTMAPK8ABL1 | |
| SCHEMBL17837358 | 0.83 | SYK (0.52) | SYKMAPK1HTTSRCABL1 | |
| SCHEMBL15258023 | 0.82 | SYK (0.55) | SYKMAPK1HTTSRCJAK2 | |
| SCHEMBL13498135 | 0.80 | SYK (0.55) | SYKMAPK1HTTEGFRBTK | |
| SCHEMBL5658210 | 0.80 | MAPT (0.54) | SYKMAPK1HTTMAPK8AURKA | |
| SCHEMBL2627292 | 0.80 | PDE4B (0.55) | SYKMAPK1HTTMAPK8EGFR | |
| SCHEMBL2627183 | 0.80 | SYK (0.48) | SYKMAPK1HTTEGFRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176310-B1 | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents | UCB SA (GB) | 2007-02-13 | — | — | US | disclosed |