Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.53 |
| ▸ | AURKA | O14965 | 6/20 | 0.50 |
| ▸ | CDC7 | O00311 | 1/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.50 |
| ▸ | FABP4 | P15090 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1315419 | 0.92 | SYK (0.55) | MAPTALDH1A1SMN1; SMN2MAPK8SYK | |
| Fluoride SCHEMBL13518358 | 0.91 | SYK (0.54) | MAPTALDH1A1SMN1; SMN2MAPK8SYK | |
| SCHEMBL5660027 | 0.87 | MAPT (0.54) | MAPTALDH1A1SMN1; SMN2MAPK8AURKA | |
| SCHEMBL2174057 | 0.86 | MAPT (0.53) | MAPTALDH1A1SMN1; SMN2MAPK8AURKA | |
| SCHEMBL1313173 | 0.82 | MAPK8 (0.58) | MAPTALDH1A1SMN1; SMN2MAPK8SYK | |
| SCHEMBL13518357 | 0.82 | MAPK1 (0.55) | MAPTALDH1A1SMN1; SMN2MAPK8SYK | |
| SCHEMBL27519222 | 0.81 | SYK (0.55) | MAPTMAPK8AURKACDC7SYK | |
| SCHEMBL5657523 | 0.80 | SYK (0.56) | MAPTALDH1A1SMN1; SMN2MAPK8AURKA | |
| SCHEMBL15631820 | 0.79 | SYK (0.73) | MAPTALDH1A1SMN1; SMN2MAPK8SYK | |
| SCHEMBL30879292 | 0.79 | GAA (0.59) | MAPTALDH1A1SMN1; SMN2MAPK8AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176310-B1 | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents | UCB SA (GB) | 2007-02-13 | — | — | US | disclosed |