Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.48 |
| ▸ | MTOR | P42345 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | ASPH | Q12797 | 1/20 | 0.41 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5658543 | 0.83 | TRPV1 (0.67) | NAMPTTRPV1MTORMAPK1 | |
| SCHEMBL5658153 | 0.80 | TRPV1 (0.69) | NAMPTTRPV1MTOR | |
| SCHEMBL5659710 | 0.79 | TRPV1 (0.51) | TRPV1MAPK1ATG4B | |
| SCHEMBL5657810 | 0.76 | MAPK1 (0.53) | NAMPTTRPV1MTORMAPK1ATG4B | |
| SCHEMBL5443355 | 0.75 | CLK4 (0.52) | NAMPTTRPV1MTORMAPK1ATG4B | |
| SCHEMBL5658815 | 0.74 | TRPV1 (0.55) | NAMPTTRPV1MTORMAPK1ATG4B | |
| SCHEMBL5661578 | 0.73 | TRPV1 (0.71) | NAMPTTRPV1MTOR | |
| SCHEMBL5658005 | 0.71 | TRPV1 (0.65) | NAMPTTRPV1MTOR | |
| SCHEMBL5659699 | 0.71 | TRPV1 (0.53) | NAMPTTRPV1MTORMAPK1ATG4B | |
| SCHEMBL5661517 | 0.70 | TRPV1 (0.68) | NAMPTTRPV1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7285563-B2 | Heteroaromatic urea derivatives as VR-1 receptor modulators for treating pain | MERCK SHARP & DOHME LTD. (GB) | 2007-10-23 | — | — | US | disclosed |
| US-20050107388-A1 | Heteroaromatic urea derivatives as vr-1receptor modulators for treating pain | MERCK SHARP & DOHME LTD. (GB) | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107388-A1 | Heteroaromatic urea derivatives as vr-1receptor modulators for treating pain | ARRB1, OPRL1, CNR1 | NAMPT 1466/4885TRPV1 37/4885MTOR 1495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.