Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 15/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.46 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.46 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14457605 | 0.89 | TP53 (0.54) | SCN9ATP53ALDH1A1HSD17B10 | |
| SCHEMBL5658410 | 0.83 | SCN9A (0.57) | SCN9ATP53ALDH1A1NPSR1P2RX1 | |
| SCHEMBL5658331 | 0.82 | SCN9A (0.62) | SCN9ATP53ALDH1A1P2RX1P2RX3 | |
| SCHEMBL5660005 | 0.82 | ALDH1A1 (0.40) | SCN9ATP53ALDH1A1NPSR1USP2 | |
| SCHEMBL5658896 | 0.79 | SCN9A (0.65) | SCN9ATP53ALDH1A1P2RX1P2RX3 | |
| SCHEMBL5656508 | 0.76 | SCN9A (0.84) | SCN9ATP53ALDH1A1P2RX1P2RX3 | |
| SCHEMBL28992834 | 0.76 | SCN9A (0.84) | SCN9ATP53ALDH1A1P2RX1P2RX3 | |
| SCHEMBL14457630 | 0.76 | SCN9A (0.43) | SCN9AALDH1A1 | |
| SCHEMBL5661475 | 0.74 | CNR1 (0.38) | SCN9ATP53ALDH1A1NPSR1USP2 | |
| SCHEMBL5660487 | 0.74 | EDNRB (0.41) | SCN9ATP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7250442-B2 | Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY (US) | 2007-07-31 | — | — | US | disclosed |
| US-20050054712-A1 | Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054712-A1 | Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators | NR3C2, NR5A1, NR5A2 | SCN9A 1918/4885TP53 3370/4885ALDH1A1 723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.