SCHEMBL5659

SCHEMBL5659

COCCc1ccc(N)cc1

nearest known ligand 0.59

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
GFER P55789 1/20 0.59
CYP19A1 P11511 5/20 0.53
MAOB P27338 5/20 0.50
MAOA P21397 2/20 0.50
NPC1 O15118 2/20 0.48
RAB9A P51151 2/20 0.48
TDP1 Q9NUW8 3/20 0.46
ALDH1A1 P00352 2/20 0.46
CYP3A4 P08684 2/20 0.46
TSHR P16473 1/20 0.46
TAAR1 Q96RJ0 1/20 0.45
LOXL2 Q9Y4K0 1/20 0.44
MAPK1 P28482 1/20 0.42
RECQL P46063 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11206003 0.98 GFER (0.56) GFERCYP19A1MAOBMAOANPC1
SCHEMBL7146312 0.94 GFER (0.52) GFERCYP19A1MAOBMAOANPC1
SCHEMBL1338713 0.87 NR3C1 (0.44) CYP19A1MAOBTDP1TSHRTAAR1
SCHEMBL1165563 0.87 GFER (0.50) GFERCYP19A1MAOBMAOANPC1
SCHEMBL13625390 0.86 GFER (0.54) GFERCYP19A1MAOBMAOANPC1
SCHEMBL1048406 0.86 TAAR1 (0.61) MAOBTDP1ALDH1A1TSHRTAAR1
SCHEMBL11207570 0.85 MAOB (0.57) GFERCYP19A1MAOBMAOANPC1
SCHEMBL9519264 0.82 GFER (0.45) GFERCYP19A1MAOBMAOANPC1
SCHEMBL23291144 0.81 TAAR1 (0.52) GFERCYP19A1MAOBMAOAALDH1A1
SCHEMBL4459621 0.81 HRH3 (0.46) MAOBTAAR1LOXL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114763346-B Compounds for inducing cartilage formation and application thereof 华东师范大学 2025-06-10 CN disclosed
US-12264169-B2 Heteroaryl inhibitors of PDE4 Tetra Discovery Partners (US) 2025-04-01 US disclosed
WO-2025054339-A1 TRIAZOLOPYRIDINE COMPOUNDS AS INHIBITORS OF KIT ARCUS BIOSCIENCES, INC. (US) 2025-03-13 WO disclosed
EP-4065117-B1 ISOQUINOLINE DERIVATIVES FOR USE IN TREATING GLUT1 DEFICIENCY SYNDROME GLIAPHARM SA (CH) 2024-06-19 EP disclosed
US-11925632-B2 Isoquinoline derivatives for use in treating GLUT1 deficiency syndrome GLIAPHARM SA (CH) 2024-03-12 US disclosed
US-20230348501-A1 HETEROARYL INHIBITORS OF PDE4 Tetra Discovery Partners, LLC 2023-11-02 US disclosed
US-11767334-B2 Heteroaryl inhibitors of PDE4 Tetra Discovery Partners, LLC (US) 2023-09-26 US disclosed
US-20230102415-A1 ISOQUINOLINE DERIVATIVES FOR USE IN TREATING GLUT1 DEFICIENCY SYNDROME GLIAPHARM SA (CH) 2023-03-30 US disclosed
CN-111212627-B Powder composition comprising a hair substantive dye 花王株式会社 2023-02-17 CN disclosed
US-20230024240-A1 HETEROARYL INHIBITORS OF PDE4 Tetra Discovery Partners, LLC 2023-01-26 US disclosed
US-7271176-B2 Chemokine receptor antagonists and methods of use thereof MILLENNIUM PHARMACEUTICALS, INC. (US) 2007-09-18 US disclosed
WO-2006122806-A2 1,3-DIHYDRO-IMIDAZO [4,5-C] QUINOLIN-2-ONES AS LIPID KINASE INHIBITORS NOVARTIS AG (CH) 2006-11-23 WO disclosed
WO-2005105760-A1 HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF AS AN MMP-13 INHIBITOR TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2005-11-10 WO disclosed
WO-2004106292-A1 HALOETHYL UREA COMPOUNDS AND THEIR USE TO ATTENUATE, INHIBIT OR PREVENT NON-CANCEROUS PATHOGENIC CELLULAR PROLIFERATION AND DISEASES ASSOCIATED THEREWITH IMOTEP INC. (CA) 2004-12-09 WO disclosed
WO-2004106291-A1 HALOETHYL UREA COMPOUNDS AND THE USE THEREOF TO ATTENUATE, INHIBIT OR PREVENT CANCER CELL MIGRATION IMOTEP INC. (CA) 2004-12-09 WO disclosed
US-4964876-A Blue anthraquinone disperse dyes and mixtures of blue disperse dyes CIBA-GEIGY CORPORATION (US) 1990-10-23 US disclosed
EP-0344106-A2 Disperse blue dyes and mixtures of disperse blue dyes CIBA-GEIGY AG (CH) 1989-11-29 EP disclosed
US-4702906-A SHAMPOO, HAIR DYES SOCIETE ANONYME DITE: L'OREAL (FR) 1987-10-27 US disclosed
US-4517174-A Hair treatment compositions based on polycationic polymers SOCIETE ANONYME DITE: L'OREAL (FR) 1985-05-14 US disclosed
US-4411884-A Cosmetic agents based on polycationic polymers, and their use in cosmetic compositions SOCIETE ANONYME DITE: L'OREAL (FR) 1983-10-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11925632-B2 Isoquinoline derivatives for use in treating GLUT1 deficiency syndrome SLC2A1, SLC2A2, SLC2A3 GFER 3652/4885CYP19A1 1874/4885MAOB 2136/4885
US-20230024240-A1 HETEROARYL INHIBITORS OF PDE4 PDE4A, PDE4B, PDE4C GFER 2160/4885CYP19A1 1461/4885MAOB 629/4885
US-20230348501-A1 HETEROARYL INHIBITORS OF PDE4 PDE4A, PDE4B, PDE4C GFER 2160/4885CYP19A1 1461/4885MAOB 629/4885
US-11767334-B2 Heteroaryl inhibitors of PDE4 PDE4A, PDE4B, PDE4C GFER 2160/4885CYP19A1 1461/4885MAOB 629/4885
US-12264169-B2 Heteroaryl inhibitors of PDE4 PDE4A, PDE4B, PDE4C GFER 2160/4885CYP19A1 1461/4885MAOB 629/4885
US-20230102415-A1 ISOQUINOLINE DERIVATIVES FOR USE IN TREATING GLUT1 DEFICIENCY SYNDROME SLC2A1, SLC2A2, SLC2A3 GFER 3652/4885CYP19A1 1874/4885MAOB 2136/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.