Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.61 |
| ▸ | CASP1 | P29466 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5234378 | 0.94 | GSK3B (0.66) | GSK3BCASP1KMT2APOLBMAPK1 | |
| Trifluoroacetic Acid SCHEMBL5659047 | 0.93 | GSK3B (0.58) | GSK3BCASP1KMT2APOLBCYP2C9 | |
| Trifluoroacetic Acid SCHEMBL5659289 | 0.91 | GSK3B (0.63) | GSK3BCASP1KMT2APOLBMAPK1 | |
| Trifluoroacetic Acid SCHEMBL5660695 | 0.90 | GSK3B (0.73) | GSK3BCASP1KMT2APOLBMAPK1 | |
| Trifluoroacetic Acid SCHEMBL5658531 | 0.88 | GSK3B (0.61) | GSK3BCASP1KMT2APOLBMAPK1 | |
| SCHEMBL5231733 | 0.86 | GSK3B (0.63) | GSK3BCASP1KMT2APOLBMAPK1 | |
| Trifluoroacetic Acid SCHEMBL5656666 | 0.85 | GSK3B (0.73) | GSK3BCASP1MAPK1P2RX7MAPK13 | |
| SCHEMBL4847269 | 0.84 | GSK3B (0.81) | GSK3BCASP1KMT2APOLBMAPK1 | |
| SCHEMBL5235839 | 0.84 | GSK3B (0.68) | GSK3BCASP1KMT2APOLBMAPK1 | |
| SCHEMBL4856266 | 0.84 | CASP1 (0.69) | GSK3BCASP1KMT2AMAPK1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |