Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 3/20 | 0.55 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL279675 | 0.87 | — | — | |
| Trifluoroacetic Acid SCHEMBL5656425 | 0.81 | F2 (0.77) | DAOF2ALDH1A1HPGDHDAC6 | |
| Trifluoroacetic Acid SCHEMBL5660311 | 0.78 | F2 (0.46) | DAOF2ALDH1A1POLBKMT2A | |
| SCHEMBL12310794 | 0.77 | HDAC6 (0.59) | DAOALDH1A1POLBKMT2ATDP1 | |
| SCHEMBL8201304 | 0.74 | DAO (0.48) | DAOF2ALDH1A1POLBKMT2A | |
| SCHEMBL2202058 | 0.73 | F2 (0.57) | F2HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL77302 | 0.72 | — | — | |
| SCHEMBL4155363 | 0.71 | F2 (0.46) | DAOF2ALDH1A1POLBKMT2A | |
| SCHEMBL6181512 | 0.71 | F2 (0.71) | DAOF2ALDH1A1POLBKMT2A | |
| Hydrochloric Acid SCHEMBL3049773 | 0.70 | DAO (0.95) | DAOALDH1A1POLBKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |