Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5659909 | 1.00 | CYP1A2 (0.34) | CYP1A2CYP2C19MEN1KMT2ACYP2C9 | |
| SCHEMBL8272609 | 0.91 | BTK (0.35) | CYP1A2CYP2C19MEN1KMT2ACYP2C9 | |
| SCHEMBL5658347 | 0.76 | MEN1 (0.33) | CYP1A2CYP2C19MEN1KMT2ACYP2C9 | |
| SCHEMBL5658339 | 0.76 | MEN1 (0.33) | CYP1A2CYP2C19MEN1KMT2ACYP2C9 | |
| SCHEMBL5660059 | 0.70 | TSHR (0.37) | CYP1A2MEN1KMT2ACYP2C9TSHR | |
| SCHEMBL5660052 | 0.70 | TSHR (0.37) | CYP1A2MEN1KMT2ACYP2C9TSHR | |
| SCHEMBL5663036 | 0.70 | ALDH1A1 (0.34) | CYP1A2CYP2C19MEN1KMT2ATSHR | |
| SCHEMBL5663039 | 0.70 | ALDH1A1 (0.34) | CYP1A2CYP2C19MEN1KMT2ATSHR | |
| SCHEMBL5659369 | 0.69 | ALDH1A1 (0.47) | CYP1A2CYP2C19MEN1KMT2ATSHR | |
| SCHEMBL5659361 | 0.69 | ALDH1A1 (0.47) | CYP1A2CYP2C19MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070293515-A1 | 1,3-Disubstituted Heteroaryl Nmda/Nr2b Antagonists | MERCK SHARP & DOHME CORP. | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293515-A1 | 1,3-Disubstituted Heteroaryl Nmda/Nr2b Antagonists | GRIN2B, GRIN2A, GRIN1 | CYP1A2 1892/4885CYP2C19 1230/4885MEN1 3222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.