Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trovafloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.65 |
| ▸ | DRD1 | P21728 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.62 |
| ▸ | LMNA | P02545 | 5/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.62 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.62 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.56 |
| ▸ | FLT4 | P35916 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | RARB | P10826 | 1/20 | 0.56 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | XBP1 | P17861 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trovafloxacin SCHEMBL5657605 | 0.92 | DPP4 (0.77) | DPP4CHRM2DRD1KDM4ELMNA | |
| Gemifloxacin SCHEMBL5656549 | 0.91 | DPP4 (0.80) | DPP4CHRM2DRD1KDM4ELMNA | |
| Trovafloxacin SCHEMBL7034983 | 0.85 | KDM4E (0.75) | DPP4KDM4ELMNAHSD17B10ABCC4 | |
| SCHEMBL8323559 | 0.83 | DPP4 (0.73) | DPP4CHRM2DRD1KDM4ELMNA | |
| SCHEMBL8323555 | 0.83 | DPP4 (0.73) | DPP4CHRM2DRD1KDM4ELMNA | |
| Gemifloxacin SCHEMBL1950144 | 0.81 | DPP4 (1.00) | DPP4CHRM2DRD1KDM4ELMNA | |
| Gemifloxacin SCHEMBL1444728 | 0.81 | DPP4 (1.00) | DPP4CHRM2DRD1KDM4ELMNA | |
| Gemifloxacin SCHEMBL136633 | 0.81 | DPP4 (1.00) | DPP4CHRM2DRD1KDM4ELMNA | |
| Gemifloxacin SCHEMBL136634 | 0.81 | DPP4 (1.00) | DPP4CHRM2DRD1KDM4ELMNA | |
| Gemifloxacin SCHEMBL29662144 | 0.81 | DPP4 (1.00) | DPP4CHRM2DRD1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401440-A4 | METHODS OF USE OF FLUOROQUINOLONE COMPOUNDS AGAINST BACTERIA | LG LIFE SCIENCES LTD (KR) | 2006-07-05 | — | — | EP | disclosed |
| EP-1401440-A1 | METHODS OF USE OF FLUOROQUINOLONE COMPOUNDS AGAINST BACTERIA | Smithkline Beecham (US) | 2004-03-31 | — | — | EP | disclosed |
| WO-2001015695-A1 | METHODS OF USE OF FLUOROQUINOLONE COMPOUNDS AGAINST BACTERIA | SMITHKLINE BEECHAM CORPORATION (US) | 2001-03-08 | — | — | WO | disclosed |