Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Gemifloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.80 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.80 |
| ▸ | DRD1 | P21728 | 1/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.75 |
| ▸ | LMNA | P02545 | 5/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.75 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | TOP2A | P11388 | 1/20 | 0.59 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | EDNRA | P25101 | 1/20 | 0.47 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trovafloxacin SCHEMBL5660787 | 0.91 | DPP4 (0.65) | DPP4CHRM2DRD1KDM4ELMNA | |
| Gemifloxacin SCHEMBL2419850 | 0.89 | DPP4 (1.00) | DPP4CHRM2DRD1KDM4ELMNA | |
| Gemifloxacin SCHEMBL136633 | 0.89 | DPP4 (1.00) | DPP4CHRM2DRD1KDM4ELMNA | |
| Gemifloxacin SCHEMBL6930951 | 0.89 | DPP4 (1.00) | DPP4CHRM2DRD1KDM4ELMNA | |
| Gemifloxacin SCHEMBL3252334 | 0.89 | DPP4 (1.00) | DPP4CHRM2DRD1KDM4ELMNA | |
| Gemifloxacin SCHEMBL1444728 | 0.89 | DPP4 (1.00) | DPP4CHRM2DRD1KDM4ELMNA | |
| Gemifloxacin SCHEMBL136634 | 0.89 | DPP4 (1.00) | DPP4CHRM2DRD1KDM4ELMNA | |
| Gemifloxacin SCHEMBL1950144 | 0.89 | DPP4 (1.00) | DPP4CHRM2DRD1KDM4ELMNA | |
| Gemifloxacin SCHEMBL29662144 | 0.89 | DPP4 (1.00) | DPP4CHRM2DRD1KDM4ELMNA | |
| Gemifloxacin SCHEMBL13414391 | 0.89 | DPP4 (1.00) | DPP4CHRM2DRD1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401440-A4 | METHODS OF USE OF FLUOROQUINOLONE COMPOUNDS AGAINST BACTERIA | LG LIFE SCIENCES LTD (KR) | 2006-07-05 | — | — | EP | disclosed |
| EP-1223935-A4 | METHODS OF USE OF FLUOROQUINOLONE COMPOUNDS AGAINST BACTERIA | SMITHKLINE BEECHAM CORP (US) | 2004-04-28 | — | — | EP | disclosed |
| EP-1401440-A1 | METHODS OF USE OF FLUOROQUINOLONE COMPOUNDS AGAINST BACTERIA | Smithkline Beecham (US) | 2004-03-31 | — | — | EP | disclosed |
| EP-1242079-A4 | METHODS OF USE OF FLUOROQUINOLONE COMPOUNDS AGAINTS BACTERIA | SMITHKLINE BEECHAM (US) | 2003-01-22 | — | — | EP | disclosed |
| EP-1242079-A1 | METHODS OF USE OF FLUOROQUINOLONE COMPOUNDS AGAINTS BACTERIA | Smithkline Beecham (US) | 2002-09-25 | — | — | EP | disclosed |
| EP-1223935-A1 | METHODS OF USE OF FLUOROQUINOLONE COMPOUNDS AGAINST BACTERIA | SmithKline Beecham Corporation (US) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001021176-A1 | METHODS OF USE OF FLUOROQUINOLONE COMPOUNDS AGAINST BACTERIA | SMITHKLINE BEECHAM CORPORATION (US) | 2001-03-29 | — | — | WO | disclosed |
| WO-2001015695-A1 | METHODS OF USE OF FLUOROQUINOLONE COMPOUNDS AGAINST BACTERIA | SMITHKLINE BEECHAM CORPORATION (US) | 2001-03-08 | — | — | WO | disclosed |
| WO-2001000209-A1 | METHODS OF USE OF FLUOROQUINOLONE COMPOUNDS AGAINST BACTERIA | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-04 | — | — | WO | disclosed |