SCHEMBL566263

SCHEMBL566263

O=C(O)Nc1cccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
TDP1 Q9NUW8 7/20 0.41
POLB P06746 6/20 0.41
MAPT P10636 1/20 0.40
APAF1 O14727 3/20 0.40
MCL1 Q07820 2/20 0.40
GRK2 P25098 2/20 0.40
PABPC1 P11940 1/20 0.40
RECQL P46063 1/20 0.40
EIF4H Q15056 1/20 0.40
RCE1 Q9Y256 1/20 0.39
HTT P42858 2/20 0.39
PAX8 Q06710 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
KDM4E B2RXH2 3/20 0.38
ATM Q13315 3/20 0.38
NPC1 O15118 1/20 0.38
CTDSP1 Q9GZU7 2/20 0.38
APOBEC3G Q9HC16 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1547589 0.92 CNR1 (0.46) CA1CA2MAPTHTTNPSR1
SCHEMBL472662 0.91 MAPT (0.42) CA1CA2TDP1POLBMAPT
SCHEMBL10155856 0.91 CA1 (0.43) CA1CA2TDP1POLBMAPT
SCHEMBL1547718 0.90 CYP3A4 (0.46) TDP1POLBMAPTAPAF1GRK2
SCHEMBL1547671 0.89 KDM4E (0.48) CA1CA2TDP1POLBMAPT
SCHEMBL1575554 0.88 TDP1 (0.44) TDP1POLBMAPTRCE1HTT
SCHEMBL1547883 0.88 BTK (0.42) CA1CA2TDP1POLBMAPT
SCHEMBL1547694 0.88 KMT2A (0.38) CA1CA2TDP1POLBMAPT
SCHEMBL13299347 0.88 POLB (0.43) TDP1POLBMAPTRCE1HTT
SCHEMBL10039049 0.87 CYP17A1 (0.41) CA1CA2TDP1POLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8785485-B2 Animal ectoparasite-controlling agent SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-07-22 US disclosed
EP-2412240-B1 Animal ectoparasite-controlling agent SUMITOMO CHEMICAL CO (JP) 2014-05-07 EP disclosed
EP-2412239-B1 Animal ectoparasite-controlling agent SUMITOMO CHEMICAL CO (JP) 2014-04-16 EP disclosed
EP-2647285-A2 Pest control composition Sumitomo Chemical Company, Limited (JP) 2013-10-09 EP disclosed
EP-2601838-A1 PEST CONTROL COMPOSITION Sumitomo Chemical Co., Ltd (JP) 2013-06-12 EP disclosed
EP-2601835-A1 PEST CONTROL COMPOSITION Sumitomo Chemical Co., Ltd (JP) 2013-06-12 EP disclosed
EP-2601836-A1 PEST CONTROL COMPOSITION Sumitomo Chemical Company Limited (JP) 2013-06-12 EP disclosed
EP-2601837-A1 PEST CONTROL COMPOSITION Sumitomo Chemical Company, Limited (JP) 2013-06-12 EP disclosed
US-20130137682-A1 PEST CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-05-30 US disclosed
US-20130131117-A1 PEST CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-05-23 US disclosed
US-20130131118-A1 PEST CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-05-23 US disclosed
US-20130131083-A1 PEST CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-05-23 US disclosed
US-20130131116-A1 PEST CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-05-23 US disclosed
US-20130131115-A1 PEST CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-05-23 US disclosed
US-20120035218-A1 PEST CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-02-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130137682-A1 PEST CONTROL COMPOSITION H1-4, HRH4, CHRM2 CA1 989/4885CA2 742/4885TDP1 3712/4885
US-20130131115-A1 PEST CONTROL COMPOSITION HRH2, HRH4, HRH1 CA1 1176/4885CA2 1092/4885TDP1 2757/4885
US-20130131118-A1 PEST CONTROL COMPOSITION H1-4, H1-10, H1-0 CA1 1094/4885CA2 1210/4885TDP1 4020/4885
US-20130131116-A1 PEST CONTROL COMPOSITION H1-4, H1-10, H1-0 CA1 870/4885CA2 1051/4885TDP1 4115/4885
US-20130131083-A1 PEST CONTROL COMPOSITION H1-4, H1-3, H1-0 CA1 1406/4885CA2 1614/4885TDP1 3651/4885
US-20130131117-A1 PEST CONTROL COMPOSITION H1-4, H1-0, H1-2 CA1 1266/4885CA2 1302/4885TDP1 1810/4885
US-20120035218-A1 PEST CONTROL COMPOSITION CTRL, CYP4F3, CYP4B1 CA1 1471/4885CA2 1171/4885TDP1 2745/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.