SCHEMBL10155856

SCHEMBL10155856

CC(=O)Nc1cccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
POLB P06746 6/20 0.42
TDP1 Q9NUW8 6/20 0.42
APAF1 O14727 3/20 0.42
MCL1 Q07820 2/20 0.42
RECQL P46063 2/20 0.42
PABPC1 P11940 1/20 0.42
GRK2 P25098 1/20 0.42
EIF4H Q15056 1/20 0.42
NPC1 O15118 3/20 0.42
RAB9A P51151 2/20 0.42
TSHR P16473 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
MAPT P10636 2/20 0.42
SYK P43405 1/20 0.41
DNMT1 P26358 3/20 0.41
CTDSP1 Q9GZU7 2/20 0.41
APOBEC3G Q9HC16 2/20 0.41
MCHR1 Q99705 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL566263 0.91 CA1 (0.41) CA1CA2POLBTDP1APAF1
SCHEMBL1547671 0.90 KDM4E (0.48) CA1CA2POLBTDP1APAF1
SCHEMBL472654 0.90 CA1 (0.41) CA1CA2POLBTDP1APAF1
SCHEMBL472662 0.90 MAPT (0.42) CA1CA2POLBTDP1APAF1
SCHEMBL1547589 0.89 CNR1 (0.46) CA1CA2NPC1RAB9AMAPT
SCHEMBL30699794 0.89 TDP1 (0.39) CA1CA2POLBTDP1NPC1
SCHEMBL10039049 0.88 CYP17A1 (0.41) CA1CA2POLBTDP1APAF1
SCHEMBL1575554 0.87 TDP1 (0.44) POLBTDP1NPC1MAPTHTT
SCHEMBL1547718 0.87 CYP3A4 (0.46) POLBTDP1APAF1RECQLGRK2
SCHEMBL1547883 0.87 BTK (0.42) CA1CA2POLBTDP1APAF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8785485-B2 Animal ectoparasite-controlling agent SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-07-22 US disclosed
EP-2412240-B1 Animal ectoparasite-controlling agent SUMITOMO CHEMICAL CO (JP) 2014-05-07 EP disclosed
US-8507514-B2 Hydrazide compound and use of the same in pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-08-13 US disclosed
US-20130137682-A1 PEST CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-05-30 US disclosed
US-20130131118-A1 PEST CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-05-23 US disclosed
US-20130131083-A1 PEST CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-05-23 US disclosed
US-20130131116-A1 PEST CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-05-23 US disclosed
US-20130131117-A1 PEST CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-05-23 US disclosed
US-20130131115-A1 PEST CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-05-23 US disclosed
US-20120035218-A1 PEST CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-02-09 US disclosed
US-20120029038-A1 ANIMAL ECTOPARASITE-CONTROLLING AGENT SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-02-02 US disclosed
US-20120029037-A1 ANIMAL ECTOPARASITE-CONTROLLING AGENT SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-02-02 US disclosed
EP-2412240-A1 Animal ectoparasite-controlling agent Sumitomo Chemical Company, Limited (JP) 2012-02-01 EP disclosed
US-20110294840-A1 HYDRAZIDE COMPOUND AND USE OF THE SAME IN PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-12-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130137682-A1 PEST CONTROL COMPOSITION H1-4, HRH4, CHRM2 CA1 989/4885CA2 742/4885POLB 4638/4885
US-20130131115-A1 PEST CONTROL COMPOSITION HRH2, HRH4, HRH1 CA1 1176/4885CA2 1092/4885POLB 4037/4885
US-20120029037-A1 ANIMAL ECTOPARASITE-CONTROLLING AGENT H1-3, EEF1A1, H1-4 CA1 866/4885CA2 735/4885POLB 3974/4885
US-20110294840-A1 HYDRAZIDE COMPOUND AND USE OF THE SAME IN PEST CONTROL H1-4, H1-2, H1-0 CA1 1099/4885CA2 670/4885POLB 3655/4885
US-20130131118-A1 PEST CONTROL COMPOSITION H1-4, H1-10, H1-0 CA1 1094/4885CA2 1210/4885POLB 4625/4885
US-20130131116-A1 PEST CONTROL COMPOSITION H1-4, H1-10, H1-0 CA1 870/4885CA2 1051/4885POLB 4609/4885
US-20120029038-A1 ANIMAL ECTOPARASITE-CONTROLLING AGENT H1-3, HRH4, EEF1A1 CA1 1006/4885CA2 636/4885POLB 4155/4885
US-20130131083-A1 PEST CONTROL COMPOSITION H1-4, H1-3, H1-0 CA1 1406/4885CA2 1614/4885POLB 4488/4885
US-20130131117-A1 PEST CONTROL COMPOSITION H1-4, H1-0, H1-2 CA1 1266/4885CA2 1302/4885POLB 3702/4885
US-20120035218-A1 PEST CONTROL COMPOSITION CTRL, CYP4F3, CYP4B1 CA1 1471/4885CA2 1171/4885POLB 3700/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.