Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 17/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | TACR3 | P29371 | 2/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5663860 | 1.00 | TACR1 (0.44) | TACR1CES2TACR3AKR1C3AKR1C2 | |
| SCHEMBL3077103 | 0.83 | CES2 (0.50) | CES2 | |
| SCHEMBL22882574 | 0.83 | TACR1 (0.41) | TACR1CES2TACR3AKR1C3AKR1C2 | |
| SCHEMBL27744103 | 0.82 | CES2 (0.42) | TACR1CES2TACR3AKR1C3AKR1C2 | |
| SCHEMBL27744099 | 0.81 | CES2 (0.41) | TACR1CES2AKR1C3AKR1C2MAPT | |
| SCHEMBL27799813 | 0.78 | PSEN1 (0.51) | MAPT | |
| SCHEMBL6299556 | 0.77 | TACR1 (0.50) | TACR1TACR3 | |
| SCHEMBL6299562 | 0.77 | TACR1 (0.50) | TACR1TACR3 | |
| SCHEMBL5200529 | 0.76 | TACR1 (0.41) | TACR1TACR3 | |
| SCHEMBL3166569 | 0.76 | TACR1 (0.41) | TACR1TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119391687-A | Immobilized enzyme catalyst for preparing chiral alcohol and chiral ester, and preparation method and application thereof | 河南大学 | 2025-02-07 | — | — | CN | disclosed |
| US-7468437-B2 | Phenyl pyrrolidine ether tachykinin receptor antagonists | MERCK & CO., INC. (US) | 2008-12-23 | — | — | US | disclosed |
| US-7468437-B2 | Phenyl pyrrolidine ether tachykinin receptor antagonists | MERCK & CO., INC. (US) | 2008-12-23 | — | — | US | disclosed |
| US-20070043015-A1 | Phenyl pyrrolidine ether tachykinin receptor antagonists | MERCK & CO., INC. (US) | 2007-02-22 | — | — | US | disclosed |
| US-20070043015-A1 | Phenyl pyrrolidine ether tachykinin receptor antagonists | MERCK & CO., INC. (US) | 2007-02-22 | — | — | US | disclosed |
| EP-1448788-A4 | PROCESS FOR THE SYNTHESIS OF (R)-1-(3,5-BIS(TRIFLUOROMETHYL)-PHENYL)ETHAN-1-OL AND ESTERS THEREOF BY DYNAMIC KINETIC RESOLUTION | MERCK & CO INC (US) | 2006-03-29 | — | — | EP | disclosed |
| EP-1448788-A2 | PROCESS FOR THE SYNTHESIS OF (R)-1-(3,5-BIS(TRIFLUOROMETHYL)-PHENYL)ETHAN-1-OL AND ESTERS THEREOF BY DYNAMIC KINETIC RESOLUTION | Merck & Co., Inc. (US) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003043575-A2 | PROCESS FOR THE SYNTHESIS OF (R)-1-(3,5-BIS(TRIFLUOROMETHYL)-PHENYL)ETHAN-1-OL AND ESTERS THEREOF BY DYNAMIC KINETIC RESOLUTION | MERCK & CO., INC. (US) | 2003-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043015-A1 | Phenyl pyrrolidine ether tachykinin receptor antagonists | TACR1, NPSR1, TACR2 | TACR1 1/4885CES2 2938/4885TACR3 122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.