Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 4/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.38 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.33 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL49567 | 0.98 | PAOX (0.52) | PAOXHIF1AKDM4EMAPK1GNAI3 | |
| SCHEMBL28954974 | 0.98 | PAOX (0.52) | PAOXHIF1AKDM4EMAPK1GNAI3 | |
| Hydrochloric Acid SCHEMBL28412040 | 0.96 | PAOX (0.50) | PAOXHIF1AKDM4EMAPK1GNAI3 | |
| Hydrochloric Acid SCHEMBL82715 | 0.96 | PAOX (0.50) | PAOXHIF1AKDM4EMAPK1GNAI3 | |
| Trimethylammonium SCHEMBL27436237 | 0.92 | PAOX (0.47) | PAOXHIF1AKDM4EMAPK1GNAI3 | |
| SCHEMBL109078 | 0.92 | PAOX (0.61) | PAOXHIF1AKDM4EMAPK1GNAI3 | |
| Sulfuric Acid SCHEMBL5687775 | 0.90 | PAOX (0.50) | PAOXHIF1AKDM4EMAPK1GNAI3 | |
| Trimethylammonium SCHEMBL27652101 | 0.90 | PAOX (0.46) | PAOXHIF1AKDM4EMAPK1GNAI3 | |
| Trimethylammonium SCHEMBL27905567 | 0.90 | PAOX (0.46) | PAOXHIF1AKDM4EMAPK1GNAI3 | |
| SCHEMBL3508069 | 0.90 | PAOX (0.64) | PAOXHIF1AKDM4EMAPK1GNAI3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7052917-B1 | Polymerizable biotin derivatives, biotin polymer, and polymer responsive to avidin stimulation | NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) | 2006-05-30 | — | — | US | disclosed |
| EP-1201667-B1 | POLYMERIZABLE BIOTIN DERIVATIVES, BIOTIN POLYMER, AND POLYMER RESPONSIVE TO AVIDIN STIMULATION | NAT INST OF ADVANCED IND SCIEN (JP) | 2005-09-21 | — | — | EP | disclosed |
| EP-1201667-A1 | POLYMERIZABLE BIOTIN DERIVATIVES, BIOTIN POLYMER, AND POLYMER RESPONSIVE TO AVIDIN STIMULATION | National Institute of Advanced Industrial Science and Technology (JP) | 2002-05-02 | — | — | EP | disclosed |