Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 12/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.41 |
| ▸ | PTGFR | P43088 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5666303 | 0.86 | MTTP (0.56) | MTTPTRPV1 | |
| SCHEMBL4981773 | 0.85 | MTTP (0.63) | MTTP | |
| SCHEMBL5664430 | 0.85 | TRPV1 (0.51) | MTTPTRPV1SORT1 | |
| SCHEMBL4984140 | 0.83 | MTTP (0.49) | MTTPSORT1PTGFRNPC1RAB9A | |
| SCHEMBL6770277 | 0.82 | TRPV1 (0.52) | TRPV1TP53SMN1; SMN2MEN1NPC1 | |
| SCHEMBL4986283 | 0.76 | MTTP (0.59) | MTTP | |
| SCHEMBL4993382 | 0.76 | MTTP (0.59) | MTTP | |
| SCHEMBL27673054 | 0.74 | MTTP (0.53) | MTTP | |
| SCHEMBL27673052 | 0.74 | MTTP (0.53) | MTTP | |
| SCHEMBL4987243 | 0.74 | MTTP (0.60) | MTTPNPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716137-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | Pfizer Products Incorporated (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080373-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2005-09-01 | — | — | WO | disclosed |