Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BPTF | Q12830 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.31 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5665690 | 0.95 | — | — | |
| SCHEMBL3487895 | 0.84 | BPTF (0.42) | BPTFACVR1CA12CA9 | |
| SCHEMBL3488028 | 0.81 | CA12 (0.44) | ABCB1ABCC1ABCG2KDM4EALDH1A1 | |
| SCHEMBL3488025 | 0.73 | ALDH1A1 (0.44) | ABCB1ABCC1ABCG2KDM4EALDH1A1 | |
| SCHEMBL5613977 | 0.70 | MLNR (0.41) | BPTFACVR1 | |
| SCHEMBL5665685 | 0.70 | — | — | |
| SCHEMBL3486729 | 0.67 | TMPRSS2 (0.38) | ACVR1ALDH1A1HPGDCA12CA9 | |
| SCHEMBL3487448 | 0.65 | CA12 (0.46) | KDM4EALDH1A1HPGDCA12CA9 | |
| SCHEMBL3488115 | 0.65 | EPHX1 (0.43) | CA12CA9 | |
| SCHEMBL3487497 | 0.64 | CA12 (0.40) | CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838686-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006073363-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | WO | disclosed |