Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 4/20 | 0.37 |
| ▸ | JAK2 | O60674 | 4/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | YES1 | P07947 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3487939 | 0.81 | DGAT1 (0.42) | STAT6JAK2DGAT1MAPTALDH1A1 | |
| SCHEMBL3487943 | 0.73 | NR1H2 (0.44) | STAT6JAK2DGAT1MAPTALDH1A1 | |
| SCHEMBL3487282 | 0.73 | NR1H2 (0.46) | STAT6JAK2SYKIGF1RZAP70 | |
| SCHEMBL3487718 | 0.66 | NR1H2 (0.58) | JAK2SYKIGF1RZAP70ABL1 | |
| SCHEMBL4690096 | 0.65 | NR1H2 (0.51) | STAT6JAK2SYKFLT3ABL1 | |
| SCHEMBL3487297 | 0.64 | NR1H2 (0.46) | STAT6JAK2MAPTMAPK1ALDH1A1 | |
| SCHEMBL3487580 | 0.63 | NR1H2 (0.54) | JAK2SYKIGF1RZAP70ABL1 | |
| SCHEMBL3488372 | 0.62 | NR1H2 (0.53) | JAK2SYKDGAT1IGF1RZAP70 | |
| SCHEMBL3487254 | 0.61 | NR1H2 (0.60) | JAK2SYKIGF1RZAP70MAPT | |
| SCHEMBL4685753 | 0.61 | NR1H2 (0.41) | STAT6JAK2SYKIGF1RFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838686-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006073363-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | WO | disclosed |