Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.50 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.50 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.50 |
| ▸ | ABAT | P80404 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | TTR | P02766 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | NQO1 | P15559 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9958281 | 0.81 | ALDH1A1 (0.72) | ALDH1A1AOX1HPGDTRIM24ALDH5A1 | |
| SCHEMBL6132027 | 0.79 | ALDH1A1 (0.70) | ALDH1A1AOX1HPGDTRIM24ALDH5A1 | |
| Isovanillin SCHEMBL1535672 | 0.78 | ALDH1A1 (1.00) | ALDH1A1AOX1HPGDPTGS2TRIM24 | |
| Isovanillin SCHEMBL29396443 | 0.78 | ALDH1A1 (1.00) | ALDH1A1AOX1HPGDPTGS2TRIM24 | |
| Isovanillin SCHEMBL70256 | 0.78 | ALDH1A1 (1.00) | ALDH1A1AOX1HPGDPTGS2TRIM24 | |
| SCHEMBL4851187 | 0.78 | ALDH1A1 (0.48) | ALDH1A1AOX1HPGDPTGS2TRIM24 | |
| SCHEMBL14873050 | 0.77 | CA1 (0.56) | ALDH1A1TDP1KDM4ETSHRCYP1A2 | |
| SCHEMBL1748746 | 0.76 | ALDH1A1 (0.58) | ALDH1A1HPGDTDP1KDM4ETSHR | |
| SCHEMBL18196640 | 0.75 | ALDH1A1 (0.73) | ALDH1A1AOX1HPGDPTGS2TRIM24 | |
| Isovanillin SCHEMBL28052909 | 0.75 | ALDH1A1 (0.93) | ALDH1A1AOX1HPGDPTGS2TRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1032559-B1 | AMINOALKYLPHENOL DERIVATIVES FOR TREATING DEPRESSION AND MEMORY DYSFUNCTION | AVENTIS PHARMA INC (US) | 2006-11-29 | — | — | EP | disclosed |
| EP-1032559-A4 | AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2005-05-25 | — | — | EP | disclosed |
| US-6479495-B1 | SIMULTANEOUSLY TREATING DEPRESSION AND MEMORY DYSFUNCTION IN MAMMALS SUFFERING FROM MEMORY DYSFUNCTION AND DEPRESSION | AVENTIS PHARMACEUTICALS INC. | 2002-11-12 | — | — | US | disclosed |
| EP-1032559-A1 | AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 2000-09-06 | — | — | EP | disclosed |
| WO-1999016746-A1 | AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 1999-04-08 | — | — | WO | disclosed |