Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 2-Aminopurine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Aminopurine SCHEMBL5631 | 0.86 | ALDH1A1 (0.48) | RXFP1ALDH1A1XDHCLK1MAPT | |
| 2-Aminopurine SCHEMBL29901502 | 0.86 | ALDH1A1 (0.48) | RXFP1ALDH1A1XDHCLK1MAPT | |
| 2-Aminopurine SCHEMBL28283405 | 0.84 | ALDH1A1 (0.47) | RXFP1ALDH1A1XDHCLK1MAPT | |
| 2-Aminopurine SCHEMBL8343847 | 0.83 | ALDH1A1 (0.41) | RXFP1ALDH1A1MAPTPARP1PRKCI | |
| 2-Aminopurine SCHEMBL20305128 | 0.83 | ALDH1A1 (0.41) | RXFP1ALDH1A1MAPTPARP1PRKCI | |
| 2-Aminopurine SCHEMBL383841 | 0.83 | ALDH1A1 (0.41) | RXFP1ALDH1A1MAPTPARP1PRKCI | |
| 2-Aminopurine SCHEMBL1528157 | 0.81 | ALDH1A1 (0.42) | RXFP1ALDH1A1MAPTPRKCIKDM4E | |
| 2-Aminopurine SCHEMBL4342851 | 0.80 | ALDH1A1 (0.41) | RXFP1ALDH1A1MAPTKDM4EDHFR | |
| 2-Aminopurine SCHEMBL10551243 | 0.78 | ALDH1A1 (0.42) | RXFP1ALDH1A1L3MBTL1MAPTKDM4E | |
| Purine SCHEMBL3004998 | 0.77 | RXFP1 (0.43) | RXFP1CYP3A4NAMPTXDHMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490101-A4 | METHODS OF ENHANCING IMMUNE INDUCTION INVOLVING MDA-7 | UNIV TEXAS (US) | 2006-09-20 | — | — | EP | disclosed |
| EP-1490101-A1 | METHODS OF ENHANCING IMMUNE INDUCTION INVOLVING MDA-7 | BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM (US) | 2004-12-29 | — | — | EP | disclosed |
| US-20040009939-A1 | Methods of enhancing immune induction involving MDA-7 | BOARD OF REGENT, THE UNIVERSITY OF TEXAS SYSTEM | 2004-01-15 | — | — | US | disclosed |
| WO-2003075952-A1 | METHODS OF ENHANCING IMMUNE INDUCTION INVOLVING MDA-7 | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2003-09-18 | — | — | WO | disclosed |