SCHEMBL5667902

SCHEMBL5667902

CC(C)(C)c1cc(C=CC(=O)C(C)(C)P(=O)(O)O)cc(C(C)(C)C)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 5/20 0.42
MAPT P10636 4/20 0.42
TP53 P04637 2/20 0.42
MAPK1 P28482 2/20 0.42
CYP3A4 P08684 1/20 0.42
ALOX15 P16050 1/20 0.42
BLM P54132 1/20 0.42
CASP7 P55210 1/20 0.42
HSD17B10 Q99714 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
CYP1A2 P05177 1/20 0.41
HMGCR P04035 1/20 0.40
GABBR2 O75899 1/20 0.36
GABBR1 Q9UBS5 1/20 0.36
KMT2A Q03164 2/20 0.35
PAX8 Q06710 1/20 0.35
GABRA1 P14867 1/20 0.34
GABRB2 P47870 1/20 0.34
NPC1 O15118 3/20 0.33
RAB9A P51151 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5667900 1.00 SMN1; SMN2 (0.42) SMN1; SMN2MAPTTP53MAPK1CYP3A4
SCHEMBL6681212 0.82 HMGCR (0.43) SMN1; SMN2MAPTTP53MAPK1CYP3A4
SCHEMBL5670145 0.82 HMGCR (0.43) SMN1; SMN2MAPTTP53MAPK1CYP3A4
SCHEMBL6918142 0.81 GABBR2 (0.59) CYP1A2HMGCRGABBR2GABBR1
SCHEMBL5668624 0.80 HMGCR (0.53) SMN1; SMN2MAPTTP53MAPK1CYP3A4
SCHEMBL5668629 0.80 HMGCR (0.53) SMN1; SMN2MAPTTP53MAPK1CYP3A4
SCHEMBL7063106 0.79 CYP1A2 (0.57) CYP3A4CYP1A2
SCHEMBL7063102 0.79 CYP1A2 (0.57) CYP3A4CYP1A2
SCHEMBL7065034 0.78 TNFRSF1A (0.50) MAPTTP53CYP3A4CASP7HSD17B10
SCHEMBL6916935 0.78 TNFRSF1A (0.50) MAPTTP53CYP3A4CASP7HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1551418-A4 SUBSTITUTED KETOPHOSPHONATE COMPOUNDS HAVING BONE ANABOLIC ACTIVITY ILEX ONCOLOGY RES SARL (CH) 2006-05-03 EP disclosed
EP-1551418-A1 SUBSTITUTED KETOPHOSPHONATE COMPOUNDS HAVING BONE ANABOLIC ACTIVITY Ilex Oncology Research Sàrl (CH) 2005-07-13 EP disclosed
WO-2004026315-A1 SUBSTITUTED KETOPHOSPHONATE COMPOUNDS HAVING BONE ANABOLIC ACTIVITY ILEX ONCOLOGY RESEARCH, SARL (CH) 2004-04-01 WO disclosed
WO-2004026243-A2 THERAPEUTIC USES OF LINEAR KETOPHOSPHONATES ILEX ONCOLOGY RESEARCH, SARL (CH) 2004-04-01 WO disclosed
WO-2004026242-A2 SUBSTITUTED KETOPHOSPHONATE INHIBITORS OF TUMOR CELL PROLIFERATION ILEX ONCOLOGY RESEARCH, SARL (CH) 2004-04-01 WO disclosed