Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.33 |
| ▸ | HMGCR | P04035 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5667947 | 1.00 | TNFRSF1A (0.33) | TNFRSF1AHMGCRHPGDALDH1A1TP53 | |
| SCHEMBL5669835 | 0.86 | TNFRSF1A (0.36) | TNFRSF1A | |
| SCHEMBL5669840 | 0.86 | TNFRSF1A (0.36) | TNFRSF1A | |
| SCHEMBL5667579 | 0.86 | TNFRSF1A (0.33) | TNFRSF1AHMGCR | |
| SCHEMBL5667576 | 0.86 | TNFRSF1A (0.33) | TNFRSF1AHMGCR | |
| SCHEMBL5662849 | 0.82 | TNFRSF1A (0.34) | TNFRSF1A | |
| SCHEMBL5668154 | 0.81 | TNFRSF1A (0.35) | TNFRSF1AHPGDALDH1A1TP53MAPK1 | |
| SCHEMBL5663920 | 0.81 | RXRA (0.38) | TNFRSF1AHMGCRTP53 | |
| SCHEMBL5668157 | 0.81 | TNFRSF1A (0.35) | TNFRSF1AHPGDALDH1A1TP53MAPK1 | |
| SCHEMBL5667234 | 0.80 | TNFRSF1A (0.34) | TNFRSF1AHPGDALDH1A1TP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551418-A4 | SUBSTITUTED KETOPHOSPHONATE COMPOUNDS HAVING BONE ANABOLIC ACTIVITY | ILEX ONCOLOGY RES SARL (CH) | 2006-05-03 | — | — | EP | disclosed |
| EP-1551418-A1 | SUBSTITUTED KETOPHOSPHONATE COMPOUNDS HAVING BONE ANABOLIC ACTIVITY | Ilex Oncology Research Sàrl (CH) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004026243-A2 | THERAPEUTIC USES OF LINEAR KETOPHOSPHONATES | ILEX ONCOLOGY RESEARCH, SARL (CH) | 2004-04-01 | — | — | WO | disclosed |
| WO-2004026315-A1 | SUBSTITUTED KETOPHOSPHONATE COMPOUNDS HAVING BONE ANABOLIC ACTIVITY | ILEX ONCOLOGY RESEARCH, SARL (CH) | 2004-04-01 | — | — | WO | disclosed |
| WO-2004026242-A2 | SUBSTITUTED KETOPHOSPHONATE INHIBITORS OF TUMOR CELL PROLIFERATION | ILEX ONCOLOGY RESEARCH, SARL (CH) | 2004-04-01 | — | — | WO | disclosed |