Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13365141 | 1.00 | MAPT (0.35) | MAPTNFKB1KDM4ETHRBALOX15 | |
| SCHEMBL14350669 | 1.00 | MAPT (0.35) | MAPTNFKB1KDM4ETHRBALOX15 | |
| SCHEMBL4337970 | 0.83 | CNR2 (0.35) | CNR2MMP1TGFBR1ADAM17CYP2C9 | |
| SCHEMBL4332752 | 0.83 | CNR2 (0.35) | CNR2MMP1TGFBR1ADAM17CYP2C9 | |
| SCHEMBL23855055 | 0.81 | TGFBR1 (0.36) | MAPTNFKB1KDM4ETHRBALOX15 | |
| SCHEMBL4344892 | 0.81 | CNR2 (0.34) | CNR2CTRB1MMP1 | |
| SCHEMBL12086289 | 0.81 | KDM4E (0.35) | MAPTNFKB1KDM4ETHRBALOX15 | |
| SCHEMBL14376297 | 0.81 | KDM4E (0.35) | MAPTNFKB1KDM4ETHRBALOX15 | |
| SCHEMBL4338681 | 0.81 | CNR2 (0.34) | CNR2CTRB1MMP1 | |
| SCHEMBL394954 | 0.81 | TGFBR1 (0.36) | MAPTNFKB1KDM4ETHRBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730141-A1 | COMPOUNDS FOR THE TREATMENT OF DISEASES | Pfizer Limited (GB) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005092887-A1 | COMPOUNDS FOR THE TREATMENT OF DISEASES | PFIZER LIMITED (GB) | 2005-10-06 | — | — | WO | disclosed |