Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 6/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5182869 | 1.00 | L3MBTL1 (0.44) | L3MBTL1NR5A1FAAHTDP1THRA | |
| SCHEMBL14814379 | 0.88 | L3MBTL1 (0.40) | L3MBTL1FAAHTDP1MEN1MAPT | |
| SCHEMBL9699861 | 0.87 | L3MBTL1 (0.44) | L3MBTL1NR5A1FAAHTDP1THRA | |
| SCHEMBL1228883 | 0.87 | L3MBTL1 (0.44) | L3MBTL1NR5A1FAAHTDP1THRA | |
| SCHEMBL27294182 | 0.87 | L3MBTL1 (0.44) | L3MBTL1NR5A1FAAHTDP1THRA | |
| SCHEMBL9699956 | 0.87 | L3MBTL1 (0.44) | L3MBTL1NR5A1FAAHTDP1THRA | |
| SCHEMBL27501834 | 0.85 | L3MBTL1 (0.45) | L3MBTL1NR5A1TDP1THRATHRB | |
| SCHEMBL17416897 | 0.84 | NR5A1 (0.42) | NR5A1THRATHRBMEN1NR1I2 | |
| SCHEMBL3458097 | 0.84 | NR5A1 (0.42) | NR5A1THRATHRBMEN1NR1I2 | |
| SCHEMBL6200775 | 0.84 | NR5A1 (0.42) | NR5A1THRATHRBMEN1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1729755-A1 | METHODS OF TREATMENT OF AMYLOIDOSIS USING ASPARTYL-PROTEASE INIHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005070407-A1 | METHODS OF TREATMENT OF AMYLOIDOSIS USING ASPARTYL-PROTEASE INIHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 2005-08-04 | — | — | WO | disclosed |