Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 5/20 | 0.47 |
| ▸ | CA2 | P00918 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17351029 | 0.80 | CA1 (0.47) | CA1CA2ALDH1A1TP53KDM4E | |
| SCHEMBL17440384 | 0.80 | CA1 (0.47) | CA1CA2ALDH1A1TP53KDM4E | |
| SCHEMBL16954014 | 0.80 | CA1 (0.47) | CA1CA2ALDH1A1TP53KDM4E | |
| SCHEMBL6331609 | 0.80 | CA1 (0.52) | CA1CA2ALDH1A1TP53KDM4E | |
| 2-Methoxyresorcinol SCHEMBL69297 | 0.78 | CA2 (0.61) | CA1CA2ALDH1A1TP53KDM4E | |
| SCHEMBL17194896 | 0.78 | TSHR (0.40) | ALDH1A1KDM4EMAPK1LMNACYP3A4 | |
| SCHEMBL30174376 | 0.78 | SMN1; SMN2 (0.45) | CA1CA2ALDH1A1TP53KDM4E | |
| SCHEMBL6196015 | 0.78 | SMN1; SMN2 (0.45) | CA1CA2ALDH1A1TP53KDM4E | |
| SCHEMBL16957966 | 0.77 | MEN1 (0.33) | CA1CA2ALDH1A1KDM4EMAPK1 | |
| SCHEMBL16959666 | 0.76 | KDM4E (0.33) | ALDH1A1KDM4EMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1032559-B1 | AMINOALKYLPHENOL DERIVATIVES FOR TREATING DEPRESSION AND MEMORY DYSFUNCTION | AVENTIS PHARMA INC (US) | 2006-11-29 | — | — | EP | disclosed |
| EP-1032559-A4 | AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2005-05-25 | — | — | EP | disclosed |
| US-6479495-B1 | SIMULTANEOUSLY TREATING DEPRESSION AND MEMORY DYSFUNCTION IN MAMMALS SUFFERING FROM MEMORY DYSFUNCTION AND DEPRESSION | AVENTIS PHARMACEUTICALS INC. | 2002-11-12 | — | — | US | disclosed |
| EP-1032559-A1 | AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 2000-09-06 | — | — | EP | disclosed |
| WO-1999016746-A1 | AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 1999-04-08 | — | — | WO | disclosed |