Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.43 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.43 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL491488 | 0.77 | PPARD (0.54) | CYP1A2MEN1KMT2AGABBR2GABBR1 | |
| SCHEMBL13725451 | 0.74 | PPARD (0.59) | CYP1A2MEN1KMT2AGABBR2GABBR1 | |
| SCHEMBL9062818 | 0.72 | GABBR2 (0.55) | CYP1A2MEN1KMT2AGABBR2GABBR1 | |
| SCHEMBL9203692 | 0.71 | PPARD (0.52) | CYP1A2MEN1KMT2AGABBR2GABBR1 | |
| SCHEMBL29374057 | 0.70 | PPARD (0.50) | CYP1A2MEN1KMT2AGABBR2GABBR1 | |
| SCHEMBL5841645 | 0.70 | PPARD (0.50) | CYP1A2MEN1KMT2AGABBR2GABBR1 | |
| SCHEMBL14189812 | 0.70 | PPARD (0.50) | CYP1A2MEN1KMT2AGABBR2GABBR1 | |
| SCHEMBL15927961 | 0.70 | PPARD (0.50) | CYP1A2MEN1KMT2AGABBR2GABBR1 | |
| Oxalic Acid SCHEMBL3175186 | 0.69 | PPARD (0.50) | CYP1A2MEN1KMT2AGABBR2GABBR1 | |
| SCHEMBL5664086 | 0.69 | TSHR (0.41) | CYP1A2MEN1KMT2AGABBR2GABBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1408971-A4 | NOVEL QUINOLINES AND USES THEREOF | ARIAD PHARMA INC (US) | 2006-01-25 | — | — | EP | disclosed |
| EP-1408971-A1 | NOVEL QUINOLINES AND USES THEREOF | ARIAD PHARMACEUTICALS, INC. (US) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003000266-A1 | NOVEL QUINOLINES AND USES THEREOF | ARIAD PHARMACEUTICALS, INC. (US) | 2003-01-03 | — | — | WO | disclosed |