Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 7/20 | 0.59 |
| ▸ | F2 | P00734 | 3/20 | 0.53 |
| ▸ | PLG | P00747 | 2/20 | 0.53 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.53 |
| ▸ | KLK1 | P06870 | 2/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | PLAT | P00750 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | F7 | P08709 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5670526 | 0.90 | PLAU (0.56) | PLAUF2PLGKLKB1KLK1 | |
| SCHEMBL5672471 | 0.83 | PLAU (0.48) | PLAUF2PLGKLKB1KLK1 | |
| SCHEMBL7075852 | 0.82 | TDP1 (0.49) | PLAUF2PRSS1CES1F10 | |
| SCHEMBL5431379 | 0.81 | PLAU (0.59) | PLAUF2PLGKLKB1KLK1 | |
| SCHEMBL10588465 | 0.81 | ESR1 (0.49) | PLAUF2PLGKLKB1KLK1 | |
| SCHEMBL5430181 | 0.78 | PLAU (0.56) | PLAUF2PLGKLKB1KLK1 | |
| SCHEMBL11848661 | 0.78 | ESR1 (0.59) | PLAUF2PLGKLKB1KLK1 | |
| SCHEMBL27443700 | 0.77 | ESR1 (0.78) | PLAUF2PLGKLKB1KLK1 | |
| SCHEMBL5051900 | 0.76 | KDM4E (0.58) | PLAUESR1ESR2CES2CES1 | |
| SCHEMBL8010469 | 0.75 | ESR1 (0.52) | PLAUESR1ESR2CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646371-A2 | ANTIVIRAL COMPOUNDS AND METHODS | Biotron Limited (AU) | 2006-04-19 | — | — | EP | claimed |
| WO-2004112687-A2 | ANTIVIRAL ACYLGUANIDINE COMPOUNDS AND METHODS | BIOTRON LIMITED (AU) | 2004-12-29 | — | — | WO | claimed |
| EP-2617709-A1 | Guanidine derivatives as antiviral agents | Biotron Limited (AU) | 2013-07-24 | — | — | EP | disclosed |
| EP-1646371-A2 | ANTIVIRAL COMPOUNDS AND METHODS | Biotron Limited (AU) | 2006-04-19 | — | — | EP | disclosed |
| WO-2004112687-A2 | ANTIVIRAL ACYLGUANIDINE COMPOUNDS AND METHODS | BIOTRON LIMITED (AU) | 2004-12-29 | — | — | WO | disclosed |