Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 12/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5130748 | 0.84 | SMN1; SMN2 (0.53) | SMN1; SMN2EPHX1KDM4EALDH1A1EPHX2 | |
| SCHEMBL5130749 | 0.84 | SMN1; SMN2 (0.53) | SMN1; SMN2EPHX1KDM4EALDH1A1EPHX2 | |
| SCHEMBL19753551 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2EPHX1KDM4EALDH1A1 | |
| SCHEMBL15384058 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2EPHX1KDM4EALDH1A1 | |
| SCHEMBL19753546 | 0.82 | SMN1; SMN2 (0.41) | SMN1; SMN2EPHX1KDM4EALDH1A1EPHX2 | |
| SCHEMBL2254202 | 0.81 | ALDH1A1 (0.46) | SMN1; SMN2EPHX1ALDH1A1EPHX2 | |
| SCHEMBL2244920 | 0.81 | ALDH1A1 (0.46) | SMN1; SMN2EPHX1ALDH1A1EPHX2 | |
| SCHEMBL24107359 | 0.81 | EPHX1 (0.41) | SMN1; SMN2EPHX1EPHX2 | |
| SCHEMBL15414684 | 0.80 | EPHX1 (0.39) | EPHX1KDM4EALDH1A1EPHX2THRB | |
| SCHEMBL2247729 | 0.79 | ALDH1A1 (0.43) | SMN1; SMN2EPHX1ALDH1A1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1729755-A1 | METHODS OF TREATMENT OF AMYLOIDOSIS USING ASPARTYL-PROTEASE INIHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005070407-A1 | METHODS OF TREATMENT OF AMYLOIDOSIS USING ASPARTYL-PROTEASE INIHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 2005-08-04 | — | — | WO | disclosed |