Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 10/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29624163 | 0.79 | EPHX1 (0.43) | EPHX1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL7747174 | 0.79 | MEN1 (0.46) | KDM4EALDH1A1MEN1KMT2AEPHX2 | |
| SCHEMBL7742434 | 0.79 | MEN1 (0.46) | KDM4EALDH1A1MEN1KMT2AEPHX2 | |
| SCHEMBL7748093 | 0.79 | MEN1 (0.46) | KDM4EALDH1A1MEN1KMT2AEPHX2 | |
| SCHEMBL21842299 | 0.78 | KDM4E (0.52) | EPHX1KDM4EMEN1KMT2AEPHX2 | |
| SCHEMBL8552632 | 0.77 | KMT2A (0.50) | EPHX1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL23841857 | 0.77 | SMN1; SMN2 (0.46) | EPHX1EPHX2 | |
| SCHEMBL21842363 | 0.77 | MEN1 (0.42) | EPHX1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL7746769 | 0.76 | MEN1 (0.43) | KDM4EALDH1A1MEN1KMT2AEPHX2 | |
| SCHEMBL23975142 | 0.76 | NAAA (0.60) | EPHX1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1729755-A1 | METHODS OF TREATMENT OF AMYLOIDOSIS USING ASPARTYL-PROTEASE INIHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005070407-A1 | METHODS OF TREATMENT OF AMYLOIDOSIS USING ASPARTYL-PROTEASE INIHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 2005-08-04 | — | — | WO | disclosed |