Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | SLC8A1 | P32418 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4964149 | 0.91 | OPRM1 (0.47) | OPRM1OPRD1OPRK1HDAC1SLC8A1 | |
| SCHEMBL4963721 | 0.83 | SLC8A1 (0.39) | OPRM1OPRD1OPRK1HDAC1SLC8A1 | |
| SCHEMBL4964601 | 0.79 | OPRM1 (0.57) | OPRM1OPRD1OPRK1HDAC1PDE5A | |
| Hydrochloric Acid SCHEMBL4968080 | 0.79 | OPRM1 (0.56) | OPRM1OPRD1OPRK1HDAC1PDE5A | |
| SCHEMBL4965333 | 0.76 | OPRM1 (0.54) | OPRM1OPRD1OPRK1HDAC1PDE5A | |
| SCHEMBL14369648 | 0.74 | F2 (0.34) | OPRM1OPRD1OPRK1 | |
| SCHEMBL4966800 | 0.73 | OPRM1 (0.51) | OPRM1OPRD1OPRK1HDAC1PDE5A | |
| SCHEMBL4965646 | 0.73 | OPRM1 (0.41) | OPRM1OPRD1OPRK1HDAC1SLC8A1 | |
| SCHEMBL4968119 | 0.72 | OPRM1 (0.40) | OPRM1OPRD1OPRK1HDAC1PDE5A | |
| Hydrochloric Acid SCHEMBL4965277 | 0.72 | OPRM1 (0.41) | OPRM1OPRD1OPRK1HDAC1SLC8A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730140-A1 | OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-12-13 | — | — | EP | claimed |
| WO-2005090337-A1 | OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-09-29 | — | — | WO | claimed |
| EP-1730140-A1 | OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005090337-A1 | OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-09-29 | — | — | WO | disclosed |