Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 17/20 | 0.53 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL808858 | 1.00 | NR3C1 (0.53) | NR3C1KDM5AKDM4CKDM5BMEN1 | |
| SCHEMBL808960 | 0.83 | NR3C1 (0.55) | NR3C1 | |
| SCHEMBL809023 | 0.80 | NR3C1 (0.66) | NR3C1 | |
| SCHEMBL5474786 | 0.77 | NR3C1 (0.34) | NR3C1 | |
| SCHEMBL5186118 | 0.77 | NR3C1 (0.36) | NR3C1KMT2A | |
| SCHEMBL809262 | 0.73 | NR3C1 (0.63) | NR3C1KDM5AKDM4CKDM5B | |
| SCHEMBL809261 | 0.73 | NR3C1 (0.63) | NR3C1KDM5AKDM4CKDM5B | |
| SCHEMBL808958 | 0.73 | NR3C1 (0.61) | NR3C1KDM5AKDM4CKDM5BMEN1 | |
| SCHEMBL808959 | 0.73 | NR3C1 (0.61) | NR3C1KDM5AKDM4CKDM5BMEN1 | |
| SCHEMBL809001 | 0.73 | NR3C1 (0.62) | NR3C1KDM5AKDM4CKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776119-A1 | TETRAHYDRO-NAPHTHALENE DERIVATIVES AS GLUCOCORTICOID RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006015870-A1 | TETRAHYDRO-NAPHTHALENE DERIVATIVES AS GLUCOCORTICOID RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2006-02-16 | — | — | WO | disclosed |