⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10921883 | 0.79 | — | — | |
| SCHEMBL1047273 | 0.75 | — | — | |
| SCHEMBL330756 | 0.75 | — | — | |
| SCHEMBL29511324 | 0.72 | — | — | |
| SCHEMBL4899529 | 0.72 | — | — | |
| SCHEMBL29732525 | 0.72 | — | — | |
| SCHEMBL1389468 | 0.72 | — | — | |
| SCHEMBL10780430 | 0.72 | — | — | |
| SCHEMBL1922184 | 0.70 | — | — | |
| SCHEMBL17319177 | 0.69 | MAPT (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118076348-A | N-acylhydrazone compounds capable of inhibiting NAV 1.7 and/or NAV 1.8, methods of making, compositions, uses, methods of treatment and kits using the same | 欧罗法玛实验室股份公司 | 2024-05-24 | — | — | CN | disclosed |
| CN-117924267-A | Compounds that modulate FXR (NR 1H 4) | 吉利德科学公司 | 2024-04-26 | — | — | CN | disclosed |
| CN-117924266-A | Compounds that modulate FXR (NR 1H 4) | 吉利德科学公司 | 2024-04-26 | — | — | CN | disclosed |
| CN-109476636-B | Compounds that modulate FXR (NR 1H 4) | 吉利德科学公司 | 2024-01-09 | — | — | CN | disclosed |
| CN-111825605-B | Aryl ketone amide compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2023-03-31 | — | — | CN | disclosed |
| CN-113302190-A | FXR (NR1H4) modulating compounds | 吉利德科学公司 | 2021-08-24 | — | — | CN | disclosed |
| CN-107108595-B | Novel FXR (NR1H4) modulating compounds | 吉利德科学公司 | 2021-04-06 | — | — | CN | disclosed |
| CN-109311849-B | Compounds that modulate FXR (NR1H4) | 吉利德科学公司 | 2021-02-26 | — | — | CN | disclosed |
| CN-111825605-A | Aryl ketone amide compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2020-10-27 | — | — | CN | disclosed |
| EP-1662877-B1 | 6-HALOGENO-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINES FOR COMBATING ANIMAL PESTS | MERIAL LTD (US) | 2014-12-17 | — | — | EP | disclosed |
| US-8664235-B2 | 6-Halogeno-[1,2,4]triazolo[1,5-a]pyrimidines for combating animal pests | MERIAL LIMITED (US) | 2014-03-04 | — | — | US | disclosed |
| CN-100567297-C | 6-halo- [1,2,4] triazolo [1, 5-a ] pyrimidine compounds for combating animal pests | BASF AG (DE) | 2009-12-09 | — | — | CN | disclosed |
| US-20060264446-A1 | 6-Halogeno-[1,2,4]triazolo[1,5-a]pyrimidines for combating animal pests | BASF AKTIENGESELLSCHAFT (DE) | 2006-11-23 | — | — | US | disclosed |
| CN-1849070-A | 6-halogeno-[1,2,4]triazolo[1,5-a]pyrimidines for combating animal pests | BASF AG (DE) | 2006-10-18 | — | — | CN | disclosed |
| EP-1662877-A1 | 6-HALOGENO-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINES FOR COMBATING ANIMAL PESTS | BASF AKTIENGESELLSCHAFT (DE) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005025315-A1 | 6-HALOGENO-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINES FOR COMBATING ANIMAL PESTS | BASF AKTIENGESELLSCHAFT (DE) | 2005-03-24 | — | — | WO | disclosed |