Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL430964 | 0.89 | MAPT (0.46) | SMN1; SMN2LMNAALOX15KDM4EALDH1A1 | |
| SCHEMBL5673231 | 0.85 | LMNA (0.45) | SMN1; SMN2LMNACYP3A4KDM4EALDH1A1 | |
| SCHEMBL3326043 | 0.81 | LMNA (0.58) | SMN1; SMN2LMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3325454 | 0.78 | PIM1 (0.36) | LMNAMAPK1KDM4EALDH1A1HPGD | |
| SCHEMBL428798 | 0.78 | MAPT (0.43) | SMN1; SMN2LMNAMAPK1ALOX15KDM4E | |
| SCHEMBL427561 | 0.77 | GBA1 (0.49) | SMN1; SMN2LMNAKDM4EALDH1A1HTT | |
| SCHEMBL14259010 | 0.77 | LMNA (0.56) | SMN1; SMN2LMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL426052 | 0.76 | PDE10A (0.42) | SMN1; SMN2LMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL431120 | 0.75 | MTOR (0.47) | SMN1; SMN2LMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3326484 | 0.75 | CSF1R (0.45) | ALOX15MAPTMEN1KMT2APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556140-A4 | NOVEL COMPOUNDS | SYNTA PHARMACEUTICALS CORP (US) | 2006-04-19 | — | — | EP | disclosed |
| EP-1556140-A2 | NOVEL COMPOUNDS | Synta Pharmaceuticals Corporation (US) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004035740-A2 | AROMATIC BICYCLIC HETEROCYLES TO MODULATE 1L - 12 PRODUCTION | SYNTA PHARMACEUTICALS CORP. (US) | 2004-04-29 | — | — | WO | disclosed |