Sugi Predict

Sugi Predict / Compounds / SCHEMBL5674380

SCHEMBL5674380

SCHEMBL5674380

CCOc1ccccc1C1C(=O)Nc2ccc(Cl)cc21

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TP53 P04637 4/20 0.48
▸ LMNA P02545 2/20 0.48
▸ MAPT P10636 4/20 0.46
▸ ALDH1A1 P00352 3/20 0.46
▸ GAA P10253 3/20 0.46
▸ KDM4E B2RXH2 2/20 0.46
▸ RAB9A P51151 1/20 0.46
▸ PAX8 Q06710 1/20 0.46
▸ HTR2C P28335 2/20 0.43
▸ HTR2B P41595 2/20 0.43
▸ HTR2A P28223 1/20 0.43
▸ PGR P06401 2/20 0.43
▸ CASP1 P29466 2/20 0.42
▸ GLA P06280 1/20 0.42
▸ HPGD P15428 1/20 0.42
▸ CASP7 P55210 1/20 0.42
▸ HSD17B10 Q99714 1/20 0.42
▸ TSHR P16473 4/20 0.42
▸ SMN1; SMN2 Q16637 2/20 0.42
▸ NPSR1 Q6W5P4 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5677692 0.86 CDYL2 (0.46) TP53LMNAMAPTALDH1A1KDM4E
SCHEMBL5674270 0.83 MAPT (0.47) TP53LMNAMAPTALDH1A1GAA
SCHEMBL5674777 0.82 MEN1 (0.45) TP53LMNAMAPTHTR2CPGR
SCHEMBL28741441 0.79 CACNB4 (0.44) TP53LMNAMAPTKDM4EPGR
SCHEMBL5435436 0.78 MAPT (0.56) TP53LMNAMAPTGAAPGR
SCHEMBL7462897 0.78 MAPT (0.54) TP53LMNAMAPTALDH1A1KDM4E
SCHEMBL5678514 0.78 TSHR (0.46) TP53LMNAMAPTGAAKDM4E
SCHEMBL4590461 0.76 CACNB4 (0.47) TP53LMNAMAPTPGRCASP1
SCHEMBL7463659 0.74 BRD4 (0.51) TP53LMNAMAPTGAAPGR
SCHEMBL5674359 0.73 CACNB4 (0.47) TP53LMNAMAPTHTR2CPGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7119086-B2 Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use SANOFI-AVENTIS (FR) 2006-10-10 — — US disclosed
CN-1224623-C 1-phenylsulfonyl-1, 3-dihydro-2H-indol-2-one derivatives, their preparation and their therapeutic use SANOFI ANWANTE (FR) 2005-10-26 — — CN disclosed
EP-1419150-B1 PHENYLSULFONYL-1,3-DIHYDRO-2H-INDOLE-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE SANOFI AVENTIS (FR) 2005-04-27 — — EP disclosed
CN-1533387-A 1-phenysulfonyl-1,3-dihydro-2H-indole-2-one derivatives, their preparation and their therapeutic use ����ɳŵ��-����������˾ 2004-09-29 — — CN disclosed
US-20040180878-A1 Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use SANOFI-AVENTIS (FR) 2004-09-16 — — US disclosed
EP-1419150-A2 PHENYLSULFONYL-1,3-DIHYDRO-2H-INDOLE-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE Sanofi-Aventis (FR) 2004-05-19 — — EP disclosed
WO-2003008407-A2 PHENYLSULFONYL-1,3-DIHYDRO-2H-INDOLE-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE SANOFI-SYNTHELABO (FR) 2003-01-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040180878-A1 Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use AVPR2, AVPR1A, AVPR1B TP53 973/4885LMNA 2720/4885MAPT 3026/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.