Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 4/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.51 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.51 |
| ▸ | XDH | P47989 | 2/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 3/20 | 0.44 |
| ▸ | ACACA | Q13085 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12420708 | 0.91 | PARP15 (0.58) | PARP15PARP10PARP2XDHNR1H4 | |
| SCHEMBL28323610 | 0.83 | NR1H4 (0.58) | XDHNR1H4KMT2ANR4A2GRM5 | |
| SCHEMBL416244 | 0.82 | PARP15 (0.72) | PARP15PARP10PARP2NR1H4PKM | |
| SCHEMBL28044526 | 0.81 | MAPT (0.51) | XDH | |
| SCHEMBL2885506 | 0.80 | PARP10 (0.73) | PARP15PARP10PARP2NR1H4MEN1 | |
| SCHEMBL12420703 | 0.80 | PARP10 (0.73) | PARP15PARP10PARP2NR1H4MEN1 | |
| SCHEMBL942949 | 0.79 | MEN1 (0.55) | MEN1KMT2APKM | |
| SCHEMBL1532862 | 0.78 | PARP10 (0.74) | PARP15PARP10PARP2NR1H4MEN1 | |
| SCHEMBL12420700 | 0.78 | PARP10 (0.74) | PARP15PARP10PARP2NR1H4MEN1 | |
| SCHEMBL1532841 | 0.78 | PARP10 (0.74) | PARP15PARP10PARP2NR1H4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2522657-B1 | INDOLE DERIVATIVE | TAKEDA PHARMACEUTICAL (JP) | 2016-08-03 | — | — | EP | disclosed |
| US-8642770-B2 | Indole derivative | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-02-04 | — | — | US | disclosed |
| US-8383647-B2 | Quinoline derivative | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-26 | — | — | US | disclosed |
| US-20130018073-A1 | INDOLE DERIVATIVE | Takeda Pharmaceuticl Company Limited | 2013-01-17 | — | — | US | disclosed |
| EP-2522657-A1 | INDOLE DERIVATIVE | Takeda Pharmaceutical Company Limited (JP) | 2012-11-14 | — | — | EP | disclosed |
| US-20120035213-A1 | Quinoline derivative | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2012-02-09 | — | — | US | disclosed |
| EP-2392573-A1 | QUINOLINE DERIVATIVE | Takeda Pharmaceutical Company Limited (JP) | 2011-12-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018073-A1 | INDOLE DERIVATIVE | MCHR1, MC1R, MCHR2 | PARP15 4027/4885PARP10 4093/4885PARP2 4837/4885 |
| US-20120035213-A1 | Quinoline derivative | MC1R, MCHR1, MCHR2 | PARP15 3469/4885PARP10 3589/4885PARP2 4661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.