Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 7/20 | 0.54 |
| ▸ | MEN1 | O00255 | 7/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.54 |
| ▸ | RAB9A | P51151 | 7/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | POLB | P06746 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | THRB | P10828 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | BCHE | P06276 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 2/20 | 0.54 |
| ▸ | BLM | P54132 | 2/20 | 0.54 |
| ▸ | APP | P05067 | 2/20 | 0.53 |
| ▸ | RAD52 | P43351 | 2/20 | 0.53 |
| ▸ | INSR | P06213 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL5675163 | 1.00 | HTT (0.54) | HTTMEN1KMT2ARAB9ANPSR1 | |
| SCHEMBL5676080 | 0.99 | APP (0.55) | HTTMEN1KMT2ARAB9ANPSR1 | |
| SCHEMBL5676078 | 0.99 | APP (0.55) | HTTMEN1KMT2ARAB9ANPSR1 | |
| Perchlorate SCHEMBL591993 | 0.93 | KMT2A (0.56) | HTTMEN1KMT2ARAB9ANPSR1 | |
| Perchlorate SCHEMBL29837438 | 0.93 | KMT2A (0.56) | HTTMEN1KMT2ARAB9ANPSR1 | |
| Perchlorate SCHEMBL591992 | 0.93 | KMT2A (0.56) | HTTMEN1KMT2ARAB9ANPSR1 | |
| Iodide SCHEMBL8740751 | 0.83 | ACHE (0.52) | HTTMEN1KMT2ARAB9ANPSR1 | |
| Iodide SCHEMBL8745042 | 0.83 | KMT2A (0.57) | HTTMEN1KMT2ARAB9ANPSR1 | |
| Iodide SCHEMBL8745039 | 0.83 | KMT2A (0.57) | HTTMEN1KMT2ARAB9ANPSR1 | |
| SCHEMBL13294082 | 0.81 | MEN1 (0.40) | HTTMEN1KMT2ARAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200051-B1 | AGENT FOR DYING KERATIN FIBERS | HENKEL KGAA (DE) | 2006-02-01 | — | — | EP | claimed |
| US-6770102-B1 | AROMATIC ALDEHYDES OR KETONES AND CH-ACTIVE COMPOUNDS; DOES NOT REQUIRE OXIDIZING AGENT; BRILLIANCE; COLOR DEPTH; WIDE VARIETY OF SHADES | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2004-08-03 | — | — | US | claimed |
| EP-1200051-A1 | AGENT FOR DYING KERATIN FIBERS | Henkel Kommanditgesellschaft auf Aktien (DE) | 2002-05-02 | — | — | EP | claimed |
| WO-2001013866-A1 | AGENT FOR DYING KERATIN FIBERS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2001-03-01 | — | — | WO | claimed |
| US-5891733-A | COMPRISING A BUFFER AGENT, AN OSMOTIC PRESSURE COMPENSATING AGENT,A FIRST DYE WHICH IS A CONDENSED BENZENE DERIVATIVE, A SECOND FLUORESCENT DYE, AND A CHELATING AGENT | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1999-04-06 | — | — | US | claimed |
| EP-1200051-B1 | AGENT FOR DYING KERATIN FIBERS | HENKEL KGAA (DE) | 2006-02-01 | — | — | EP | disclosed |
| US-6770102-B1 | AROMATIC ALDEHYDES OR KETONES AND CH-ACTIVE COMPOUNDS; DOES NOT REQUIRE OXIDIZING AGENT; BRILLIANCE; COLOR DEPTH; WIDE VARIETY OF SHADES | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2004-08-03 | — | — | US | disclosed |
| EP-0708334-B1 | Reagent and method for analyzing solid components in urine | SYSMEX CORP (JP) | 2001-05-23 | — | — | EP | disclosed |
| EP-0613003-B1 | A reagent for detecting malaria infected cells and a detecting method for malaria infected cells using the same | SYSMEX CORP (JP) | 2000-04-26 | — | — | EP | disclosed |
| US-5891733-A | COMPRISING A BUFFER AGENT, AN OSMOTIC PRESSURE COMPENSATING AGENT,A FIRST DYE WHICH IS A CONDENSED BENZENE DERIVATIVE, A SECOND FLUORESCENT DYE, AND A CHELATING AGENT | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1999-04-06 | — | — | US | disclosed |
| EP-0708334-A2 | Reagent and method for analyzing solid components in urine | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1996-04-24 | — | — | EP | disclosed |
| US-5470751-A | Reagent for detecting malaria infected cells and a detecting method for malaria infected cells using the same | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1995-11-28 | — | — | US | disclosed |
| EP-0613003-A1 | A reagent for detecting malaria infected cells and a detecting method for malaria infected cells using the same | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1994-08-31 | — | — | EP | disclosed |