Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Saccharin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 8/20 | 0.76 |
| ▸ | CA9 | Q16790 | 8/20 | 0.76 |
| ▸ | CA2 | P00918 | 7/20 | 0.76 |
| ▸ | CA1 | P00915 | 4/20 | 0.76 |
| ▸ | CA7 | P43166 | 3/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.76 |
| ▸ | USP2 | O75604 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.76 |
| ▸ | BCHE | P06276 | 1/20 | 0.76 |
| ▸ | CA4 | P22748 | 1/20 | 0.76 |
| ▸ | CA6 | P23280 | 1/20 | 0.76 |
| ▸ | CA5A | P35218 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.76 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.76 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Saccharin SCHEMBL8061288 | 0.98 | CA12 (0.79) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL27538830 | 0.93 | CA12 (0.81) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL28033936 | 0.92 | CA12 (0.73) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL27387484 | 0.91 | CA12 (0.85) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL8024547 | 0.89 | CA12 (0.81) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL27848168 | 0.89 | CA12 (0.88) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL10899217 | 0.89 | CA12 (0.96) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL9463482 | 0.89 | CA12 (0.96) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL10627242 | 0.89 | CA12 (0.96) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL9463164 | 0.89 | CA12 (0.96) | CA12CA9CA2CA1CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116889551-A | Compound sodium picosulfate granule with high content uniformity and preparation method thereof | 浙江和沐康医药科技有限公司 | 2023-10-17 | — | — | CN | claimed |
| CN-103284966-A | Candesartan cilexetil dispersible tablet | KUNMING YUANRUI PHARMACEUTICAL CO LTD | 2013-09-11 | — | — | CN | claimed |
| US-20060024248-A1 | Composition and method employing membrane structured solid nanoparticles for enhanced delivery of oral care actives | COMBE INCORPORATED (US) | 2006-02-02 | — | — | US | claimed |
| CN-116889551-A | Compound sodium picosulfate granule with high content uniformity and preparation method thereof | 浙江和沐康医药科技有限公司 | 2023-10-17 | — | — | CN | disclosed |
| CN-116889551-A | Compound sodium picosulfate granule with high content uniformity and preparation method thereof | 浙江和沐康医药科技有限公司 | 2023-10-17 | — | — | CN | disclosed |
| CN-103284966-A | Candesartan cilexetil dispersible tablet | KUNMING YUANRUI PHARMACEUTICAL CO LTD | 2013-09-11 | — | — | CN | disclosed |