Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.98 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5675609 | 0.99 | PTGS2 (1.00) | PTGS2PTGS1KDM4EALDH1A1LMNA | |
| SCHEMBL5826798 | 0.90 | PTGS2 (1.00) | PTGS2PTGS1KDM4E | |
| SCHEMBL7591368 | 0.89 | PTGS2 (0.81) | PTGS2PTGS1KDM4EALDH1A1LMNA | |
| SCHEMBL5373896 | 0.84 | PTGS2 (0.75) | PTGS2PTGS1KDM4EALDH1A1LMNA | |
| SCHEMBL5675569 | 0.81 | PTGS2 (0.94) | PTGS2PTGS1 | |
| SCHEMBL3161824 | 0.80 | PTGS2 (0.69) | PTGS2PTGS1 | |
| SCHEMBL3153521 | 0.80 | PTGS2 (0.69) | PTGS2PTGS1 | |
| SCHEMBL5790839 | 0.78 | PTGS2 (0.67) | PTGS2PTGS1 | |
| SCHEMBL3748251 | 0.77 | PTGS2 (0.69) | PTGS2PTGS1 | |
| SCHEMBL4720369 | 0.76 | PTGS1 (1.00) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235812-B1 | PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITORS OF COX-2 | GLAXO GROUP LTD (GB) | 2006-02-01 | — | — | EP | claimed |
| EP-1235812-A2 | PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITORS OF COX-2 | GLAXO GROUP LIMITED (GB) | 2002-09-04 | — | — | EP | claimed |
| WO-2001038311-A2 | PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITORS OF COX-2 | GLAXO GROUP LIMITED (GB) | 2001-05-31 | — | — | WO | claimed |
| EP-1235812-B1 | PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITORS OF COX-2 | GLAXO GROUP LTD (GB) | 2006-02-01 | — | — | EP | disclosed |
| US-6780869-B1 | SELECTIVE INHIBITOR OF COX-2; ANTIINFLAMMATORY AGENT | SMITHKLINE BEECHAM CORPORATION | 2004-08-24 | — | — | US | disclosed |
| CN-1399633-A | Pyrimidine derivatives | GLAXO GROUP LTD (GB) | 2003-02-26 | — | — | CN | disclosed |
| EP-1235812-A2 | PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITORS OF COX-2 | GLAXO GROUP LIMITED (GB) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001038311-A2 | PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITORS OF COX-2 | GLAXO GROUP LIMITED (GB) | 2001-05-31 | — | — | WO | disclosed |